Prevalence of human papillomavirus type 16 variants in the Federal District, Central Brazil
Prevalence of human papillomavirus type 16 variants in the Federal District, Central Brazil
复制标题
DOI：
10.1590/s0074-02762004000300007
复制
发表时间：
2004-05-01
期刊：
影响因子：
--
通讯作者：
Martins, Cláudia RF
中科院分区：
文献类型：
--
作者：
Cruz, Márcio R;Cerqueira, Daniela M;Martins, Cláudia RF
我们报告了巴西中部联邦区宫颈病变妇女中人乳头瘤病毒16型（HPV-16）变异体的患病率。我们分析了34例HPV-16样本，鉴定了E6和L1基因的序列变异，并将变异频率与疾病状态相关联。最常见的HPV-16变异体是欧洲人（50%），其次是亚裔美国人（41.2%），非洲人-1（5.9%）和非洲人-2（2.9%）。在细胞学类型的病变中，欧洲和非欧洲变异体出现的频率相同-意义不明的非典型鳞状或腺细胞，细胞学改变提示HPV感染，宫颈上皮内瘤变，鳞状细胞癌和腺癌。
We report the prevalence of human papillomavirus type 16 (HPV-16) variants in women with cervical lesions from the Federal District, Central Brazil. We analyzed 34 HPV-16 samples, identifying the sequence variations of E6 and L1 genes and correlating variant frequency with disease status. The most prevalent HPV-16 variant was the European (50%), followed by Asian-American (41.2%), African-1 (5.9%), and African-2 (2.9%). European and non-European variants appeared in equal frequencies among the cytological types of lesions - atypical squamous or glandular cells of undetermined significance, cytological alterations suggesting HPV infection, cervical intraepithelial neoplasias, squamous cell carcinoma, and adenocarcinoma.