Aspirin and Eicosapentaenoic Acid May Arrest Progressive IgA Nephropathy: A Potential Alternative to Immunosuppression
Aspirin and Eicosapentaenoic Acid May Arrest Progressive IgA Nephropathy: A Potential Alternative to Immunosuppression
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DOI：
10.2169/internalmedicine.54.4623
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发表时间：
2015-01-01
影响因子：
1.2
通讯作者：
Nangaku, Masaomi
中科院分区：
文献类型：
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作者：
Hirahashi, Junichi;Hanafusa, Norio;Nangaku, Masaomi
免疫球蛋白 (Ig) 肾病是原发性肾小球肾炎的一种常见形式，导致相当一部分患者出现终末期肾功能衰竭。免疫疗法，包括使用类固醇，被广泛用于诱导疾病缓解；然而，它可能会导致严重的副作用。我们在此报告了 3 例进行性 IgA 肾病，并在不使用类固醇的情况下联合使用阿司匹林和二十碳五烯酸 (EPA) 进行了成功治疗。联合治疗的确切机制仍不清楚；然而，阿司匹林可能会增强源自 EPA 的抗炎脂质介质的产生。需要进一步的临床试验来证实这种治疗方案。
Immunoglobulin (Ig) A nephropathy is a prevalent form of primary glomerulonephritis, which leads to end-stage renal failure in a significant proportion of patients. Immunotherapy, including steroid use, is widely used to induce disease remission; however, it can cause serious side effects. We herein report 3 cases of progressive IgA nephropathy and their successful treatment with a combination of aspirin and eicosapentaenoic acid (EPA) without the use of steroids. The precise mechanism responsible for the combination therapy is still unknown; however, aspirin may potentiate the production of anti-inflammatory lipid mediators derived from EPA. Further clinical trials are required to substantiate this treatment regimen.