Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention.
Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention.
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DOI：
10.12688/f1000research.16160.1
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Choate, Keith
中科院分区：
文献类型：
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作者：
Cheraghlou, Shayan;Lim, Young;Choate, Keith
血管肿瘤是内皮细胞的肿瘤，其中相当数量存在于儿童时期。最近的研究已经检查了血管肿瘤的许多亚型的突变景观，主要在Ras-丝裂原活化蛋白激酶（MAPK）通路内识别突变，并提供了考虑靶向治疗的独特机会。本文将总结目前对儿童血管肿瘤病理生物学的认识。
Vascular tumors are neoplasms of endothelial cells, a significant number of which present in childhood. Recent studies have examined the mutational landscape of many subtypes of vascular tumors, identifying mutations primarily within the Ras-mitogen-activated protein kinase (MAPK) pathway and providing a unique opportunity to consider targeted therapeutics. This review will summarize the current understanding of childhood vascular tumor pathobiology.