MOVEMENT PARAMETERS AND NEURAL ACTIVITY IN MOTOR CORTEX AND AREA-5
MOVEMENT PARAMETERS AND NEURAL ACTIVITY IN MOTOR CORTEX AND AREA-5
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DOI：
10.1093/cercor/4.6.590
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发表时间：
1994-11-01
期刊：
影响因子：
3.7
通讯作者：
GEORGOPOULOS, AP
中科院分区：
文献类型：
--
作者：
ASHE, J;GEORGOPOULOS, AP
研究了运动皮层上臂区和第5区单细胞活动与手臂运动在二维空间演化参数的关系。使用多元线性回归模型，其中细胞在t + tau时刻的持续脉冲活动表示为目标方向的{X， Y}分量和手在t时刻的位置，速度和加速度的函数，其中tau是时移（-200到+200毫秒）。对运动皮层290个细胞和5区207个细胞进行分析。确定决定系数（R(2)）最高的时移，并检验模型的统计显著性。运动皮层和第5区中位R(2)分别为0.581和0.530。运动皮层和第5区最高R(2)的中位位移分别为-90和+30 msec。对于大多数细胞，所有四个参数都观察到统计学上显著的关系；与目标方向的关系最显著，与加速度的关系最不显著。
The relations of ongoing single-cell activity in the arm area of the motor cortex and area 5 to parameters of evolving arm movements in two-dimensional (2D) space were investigated. A multiple linear regression model was used in which the ongoing impulse activity of cells at time t + tau was expressed as a function of the {X, Y} components of the target direction and of position, velocity, and acceleration of the hand at time t, where tau was a time shift (-200 to +200 msec). Analysis was done on 290 cells in the motor cortex and 207 cells in area 5. The time shift at which the highest coefficient of determination (R(2)) was observed was determined and the statistical significance of the model tested. The median R(2) was 0.581 and 0.530 for motor cortex and area 5, respectively. The median shift at which the highest R(2) was observed was -90 and +30 msec for motor cortex and area 5, respectively. For most cells statistically significant relations were observed to all four parameters tested; most prominent were the relations to target direction and least prominent those to acceleration.