Basic Clinical and Laboratory Features of Filoviral Hemorrhagic Fever
Basic Clinical and Laboratory Features of Filoviral Hemorrhagic Fever
复制标题
DOI：
10.1093/infdis/jir299
复制
发表时间：
2011-11-01
影响因子：
6.4
通讯作者：
Bray, Mike
中科院分区：
文献类型：
--
作者：
Kortepeter, Mark G.;Bausch, Daniel G.;Bray, Mike
丝状病毒马尔堡和埃博拉病毒在人类中引起严重的出血热（HF）。从1967年马尔堡爆发开始，医学文献中描述了30起流行病、孤立病例和意外实验室感染。我们回顾了这些报告，以确定丝状病毒HF的基本临床和实验室特征。最详细的信息是在工业化国家接受治疗的患者的描述中发现的;除了2000年在乌干达爆发的苏丹埃博拉出血热，中非的流行病报告几乎没有提供受控或客观的临床数据。除病死率外，各种丝状病毒感染的特征没有明显差异。本汇编将对应对流行病的医务工作者和试图开发丝状病毒HF动物模型的研究者具有价值。通过确定临床数据中未回答的关键问题和差距，它将有助于指导未来爆发的临床研究。
The filoviruses Marburg and Ebola cause severe hemorrhagic fever (HF) in humans. Beginning with the 1967 Marburg outbreak, 30 epidemics, isolated cases, and accidental laboratory infections have been described in the medical literature. We reviewed those reports to determine the basic clinical and laboratory features of filoviral HF. The most detailed information was found in descriptions of patients treated in industrialized countries; except for the 2000 outbreak of Ebola Sudan HF in Uganda, reports of epidemics in central Africa provided little controlled or objective clinical data. Other than the case fatality rate, there were no clear differences in the features of the various filovirus infections. This compilation will be of value to medical workers responding to epidemics and to investigators attempting to develop animal models of filoviral HF. By identifying key unanswered questions and gaps in clinical data, it will help guide clinical research in future outbreaks.