T-kininogen:: A biomarker of aging in fisher 344 rats with possible implications for the immune response
T-kininogen:: A biomarker of aging in fisher 344 rats with possible implications for the immune response
复制标题
DOI：
10.1093/gerona/61.7.641
复制
发表时间：
2006-07-01
影响因子：
5.1
通讯作者：
Sierra, Felipe
中科院分区：
文献类型：
--
作者：
Acuna-Castillo, Claudio;Leiva-Salcedo, Elias;Sierra, Felipe
激肽原(T-KG)是雄性SD大鼠衰老的可靠生物标志物。在这里，我们在一项纵向研究中证实了费舍尔344只大鼠的类似行为，无论性别。在男性中，血清T-KG水平的增加遵循指数曲线，而在女性中，这种增加最好符合线性曲线。无论男女，饮食限制都会延缓T-KG的增加。我们先前已经证明T-KG抑制T淋巴细胞的增殖。在这里，我们显示血清T-KG水平与脾细胞(最有可能是B细胞)对内毒素反应的增殖能力呈负相关。与其他炎症标志物，包括α1-酸性糖蛋白(AGP)、结合珠蛋白或白介素10，没有观察到类似的相关性。我们的结论是，血清T-KG的升高是Fisher 344衰老的一个有用的生物标志物，它与淋巴细胞增殖随年龄的降低有关，尽管因果关系尚未建立。
T-kininogen (T-KG) is a reliable biomarker of aging in male Sprague-Dawley rats. Here we confirm, in a longitudinal study, a similar behavior in Fisher 344 rats of both sexes. In males, the increase in serum levels of T-KG follows an exponential curve, whereas in females the increase is best fitted by a linear curve. In both genders, dietary restriction delays the increase in T-KG. We have previously shown that T-KG inhibits T lymphocyte proliferation. Here we show that serum T-KG levels correlate negatively with the ability of splenocytes (most likely B cells) to proliferate in response to lipopolysaccharide. A similar correlation was not observed with other markers of inflammation, including alpha 1-acid glycoprotein (AGP), haptoglobin, or interleukin-10. We conclude that the increase in serum T-KG represents a useful biomarker of aging in Fisher 344, and it correlates with decreased lymphocyte proliferation with age, although a cause-effect relationship has not been established.