Isothiourea-mediated asymmetric O- to C-carboxyl transfer of oxazolyl carbonates: structure-selectivity profiles and mechanistic studies.
Isothiourea-mediated asymmetric O- to C-carboxyl transfer of oxazolyl carbonates: structure-selectivity profiles and mechanistic studies.
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DOI：
10.1002/chem.201102847
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发表时间：
2012-02
期刊：
影响因子：
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通讯作者：
Caroline Joannesse;C. P. Johnston;Louis C. Morrill;P. Woods;M. Kieffer;Tobias A. Nigst;H. Mayr;T. Leb
中科院分区：
文献类型：
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作者：
Caroline Joannesse;C. P. Johnston;Louis C. Morrill;P. Woods;M. Kieffer;Tobias A. Nigst;H. Mayr;T. Leb
充分探讨了在恶唑基碳酸酯的不对称Steglich重排中产生高不对称诱导所需的一系列基于四氢嘧啶的异硫脲内的结构基序，交叉和动态（19）F NMR实验用于开发这种转变的机理理解。
The structural motif within a series of tetrahydropyrimidine-based isothioureas necessary for generating high asymmetric induction in the asymmetric Steglich rearrangement of oxazolyl carbonates is fully explored, with crossover and dynamic (19)F NMR experiments used to develop a mechanistic understanding of this transformation.