Randomised comparison of leucocyte-depleted versus buffy-coat-poor blood transfusion and complications after colorectal surgery
Randomised comparison of leucocyte-depleted versus buffy-coat-poor blood transfusion and complications after colorectal surgery
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DOI：
10.1016/s0140-6736(96)06168-5
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发表时间：
1996-09-28
期刊：
影响因子：
168.9
通讯作者：
Qvist, N
中科院分区：
文献类型：
--
作者：
Jensen, LS;KissmeyerNielsen, P;Qvist, N
背景异体输血与术后感染频率增加有关。我们研究了是否可以避免这种事件的术中和术后使用leucocyte-depleted blood.Methods 589例连续择期结直肠手术患者随机接受血沉棕黄层穷人（n=299）或过滤的leucocyte-depleted红细胞（n=290）时，输血指示。实际输血260例。三名患者被排除在analysis.Findings随机分配到142例患者和输血与血沉棕黄层贫血有一个显着较高的频率比155例谁被分配到这一组，但谁没有输血的伤口感染和腹腔内脓肿。(12相对于1%，p
Background Allogeneic blood transfusion is associated with an increased frequency of postoperative infection. We studied whether such events can be avoided by the intraoperative and postoperative use of leucocyte-depleted blood.Methods 589 consecutive patients scheduled for elective colorectal surgery were randomised to receive buffy-coat poor (n=299) or filtered leucocyte-depleted red-cells (n=290) when transfusion was indicated. 260 patients actually received blood transfusion. Three patients were excluded from analysis.Findings The 142 patients randomised to and transfused with buffy-coat-poor blood had a significantly higher frequency of wound infections and intra-abdominal abscesses than the 155 patients who were allocated to this group but who were not transfused. (12 vs 1%, p