Heterogeneity of Fibroblasts and Myofibroblasts in Pulmonary Fibrosis.
Heterogeneity of Fibroblasts and Myofibroblasts in Pulmonary Fibrosis.
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DOI：
10.1007/s40139-017-0134-x
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发表时间：
2017-06
影响因子：
--
通讯作者：
Hogaboam CM
中科院分区：
文献类型：
--
作者：
Habiel DM;Hogaboam CM
特发性肺纤维化（IPF）是间质性肺病的最常见形式，其发病机制未知，平均生存期为3-5年，治疗方法有限。以肺泡II型上皮细胞损失和基质细胞异常活化为特征，进行了大量工作以表征IPF肺中成纤维细胞和肌成纤维细胞的起源和活化机制。本文就成纤维细胞和肌成纤维细胞的来源及其在肺纤维化中的作用作一综述。谱系追踪实验表明，肺间质成纤维细胞和脂肪成纤维细胞、周细胞和间皮细胞分化为肌成纤维细胞。然而，上皮和骨髓来源的细胞可产生表达胶原的成纤维细胞，但不分化成肌成纤维细胞。在纤维化肺中，成纤维细胞和肌成纤维细胞存在很大的异质性。此外，有证据表明IPF中周细胞衍生的肌成纤维细胞扩增，脂肪成纤维细胞和脂肪成纤维细胞衍生的肌成纤维细胞损失。
Idiopathic Pulmonary Fibrosis (IPF) is the most common form of interstitial lung diseases of unknown eathiopathogenesis, mean survival of 3-5 years and limited therapeutics. Characterized by a loss of alveolar type II epithelial cells and aberrant activation of stromal cells, considerable effort was undertaken to characterize the origin and activation mechanisms of fibroblasts and myofibroblasts in IPF lungs. In this review, the origin and contribution of fibroblast and myofibroblasts in lung fibrosis will be summarized. Lineage tracing experiments suggested that interstitial lung fibroblasts and lipofibroblasts, pericytes and mesothelial cells differentiate into myofibroblasts. However, epithelial and bone marrow derived cells may give rise to collagen expressing fibroblasts but do not differentiate into myofibroblasts. There is great heterogeneity in fibroblasts and myofibroblasts in fibrotic lungs. Further, there is evidence for the expansion of pericyte derived myofibroblasts and loss of lipofibroblasts and lipofibroblast derived myofibroblasts in IPF.
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影响因子：
3.1
作者：
Bartis D;Crowley LE;D'Souza VK;Borthwick L;Fisher AJ;Croft AP;Pongrácz JE;Thompson R;Langman G;Buckley CD;Thickett DR
通讯作者：
Thickett DR
影响因子：
2.7
作者：
Caprioli A;Villasenor A;Wylie LA;Braitsch C;Marty-Santos L;Barry D;Karner CM;Fu S;Meadows SM;Carroll TJ;Cleaver O
通讯作者：
Cleaver O
影响因子：
5.8
作者：
Chilosi, Marco;Zamo, Alberto;Poletti, Venerino
通讯作者：
Poletti, Venerino
DOI：
10.1165/rcmb.2012-0030oc
发表时间：
2012-10-01
影响因子：
6.4
作者：
Chen, Leiling;Acciani, Thomas;Perl, Anne-Karina T.
通讯作者：
Perl, Anne-Karina T.
影响因子：
4.6
作者：
Dixit, Radhika;Ai, Xingbin;Fine, Alan
通讯作者：
Fine, Alan