Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness
Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness
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DOI：
10.1126/science.279.5349.393
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发表时间：
1998-01-16
期刊：
影响因子：
56.9
通讯作者：
Cox, N
中科院分区：
文献类型：
--
作者：
Subbarao, K;Klimov, A;Cox, N
从香港一名患有与流感一致的致命疾病的3岁儿童的气管吸入物中分离出H5N1甲型禽流感病毒（A/Hong Kong/156/97）。血清学分析显示存在H5血凝素。所有8个RNA片段均来自一种甲型禽流感病毒。血凝素在裂解位点附近含有多个碱性氨基酸，这是高致病性甲型禽流感病毒的特征。该病毒在实验接种的白普利茅斯岩鸡和白里霍恩鸡中造成87.5%至100%的死亡率。这些结果可能对全球流感监测和大流行性流感规划具有启示意义。
An avian H5N1 influenza A virus (A/Hong Kong/156/97) was isolated from a tracheal aspirate obtained from a 3-year-old child in Hong Kong with a fatal illness consistent with influenza. Serologic analysis indicated the presence of an H5 hemagglutinin. All eight RNA segments were derived from an avian influenza A virus. The hemagglutinin contained multiple basic amino acids adjacent to the cleavage site, a feature characteristic of highly pathogenic avian influenza A viruses. The virus caused 87.5 to 100 percent mortality in experimentally inoculated White Plymouth Rock and White Leghorn chickens. These results may have implications for global influenza surveillance and planning for pandemic influenza.