Place memory formation in Drosophila is independent of proper octopamine signaling
Place memory formation in Drosophila is independent of proper octopamine signaling
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DOI：
10.1007/s00359-010-0517-5
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发表时间：
2010-04-01
影响因子：
2.1
通讯作者：
Zars, Troy
中科院分区：
文献类型：
--
作者：
Sitaraman, Divya;Zars, Melissa;Zars, Troy
生物胺在建立记忆中起着关键作用。在昆虫中，章鱼胺、多巴胺和血清素在记忆形成中起着关键作用。对于果蝇来说，章鱼胺是食欲嗅觉记忆形成的必要和充分条件。章鱼胺是否在强化果蝇记忆中发挥普遍作用尚不清楚。在热箱中的位置学习将高温与狭窄腔室的一部分相关联，并将冷的、强烈偏好的温度与腔室的另一半相关联。与冷温度相关的半室可以向苍蝇提供奖励刺激，因此位置记忆由厌恶记忆和奖励记忆组成。因此，章鱼胺在位置记忆中的作用进行了测试。使用酪胺β羟化酶（T β H[M18]）的突变和用酪胺脱羧酶-2（TDC 2）基因调控元件标记的章鱼胺（和酪胺）神经元中诱发的突触传递的阻断，我们发现位置记忆的强化不依赖于正常的章鱼胺信号传导。因此，果蝇的强化机制在特定记忆类型的形成中具有专门的系统。
The biogenic amines play a critical role in establishing memories. In the insects, octopamine, dopamine, and serotonin have key functions in memory formation. For Drosophila, octopamine is necessary and sufficient for appetitive olfactory memory formation. Whether octopamine plays a general role in reinforcing memories in the fly is not known. Place learning in the heat-box associates high temperatures with one part of a narrow chamber, and a cool, strongly preferred temperature with the other half of the chamber. The cool-temperature-associated chamber half could provide a rewarding stimulus to a fly, and thus a place memory is composed of an aversive and rewarded memory component. The role of octopamine in place memory was thus tested. Using a mutation in the tyramine beta hydroxylase (T beta H[M18]) and blocking of evoked synaptic transmission in the octopamine (and tyramine) neurons labeled with a tyramine decarboxylase-2 (TDC2) gene regulatory elements we found that reinforcement of place memories is independent of normal octopamine signaling. Thus, reinforcing mechanisms in Drosophila have specialized systems in the formation of specific memory types.