Hypoxia signaling in hematopoietic stem cells: a double-edged sword.

Hypoxia signaling in hematopoietic stem cells: a double-edged sword.
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造血干细胞中的缺氧信号:一把双刃剑。

DOI:
10.1016/j.stem.2010.08.006
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发表时间:
2010
期刊:
影响因子:
23.9
通讯作者:
Kamil R. Kranc
Kamil R. Kranc
中科院分区:
医学1区
文献类型:
--
作者:
Patrick J. Pollard;Kamil R. Kranc

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虽然造血干细胞(hsc)存在于缺氧壁龛中,但造血干细胞中缺氧信号的意义尚不清楚。Takubo et al.(2010)和Simsek et al.(2010)在本期《Cell Stem Cell》中论证了缺氧通过控制HIF-1α调节造血干细胞的代谢状态,保护造血干细胞的完整性。
Although hematopoietic stem cells (HSCs) reside in hypoxic niches, the significance of hypoxia signaling in HSCs remains unclear. In this issue ofCell Stem Cell, Takubo et al. (2010) and Simsek et al. (2010) demonstrate that hypoxia regulates the metabolic state of HSCs and protects their integrity by controlling HIF-1α.
DOI: 10.1016/j.stem.2010.07.011
发表时间: 2010-09-03
期刊: Cell stem cell
影响因子: 23.9
作者:
Simsek T;Kocabas F;Zheng J;Deberardinis RJ;Mahmoud AI;Olson EN;Schneider JW;Zhang CC;Sadek HA
通讯作者: Sadek HA