Emerging roles of extracellular vesicles in the adaptive response of tumour cells to microenvironmental stress.
Emerging roles of extracellular vesicles in the adaptive response of tumour cells to microenvironmental stress.
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DOI：
10.3402/jev.v2i0.20304
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发表时间：
2013-03-05
影响因子：
16
通讯作者：
Belting M
中科院分区：
文献类型：
--
作者：
Kucharzewska P;Belting M
细胞不断受到各种内源性和外源性应激刺激，可造成严重甚至永久性损伤。因此，细胞感知和适应环境变化的能力对于在发育和成年期间维持组织稳态至关重要。在这里，我们回顾了恶性肿瘤微环境的一些主要表型特征以及细胞外囊泡在这些事件中的新作用。
Cells are constantly subjected to various types of endogenous and exogenous stressful stimuli, which can cause serious and even permanent damage. The ability of a cell to sense and adapt to environmental alterations is thus vital to maintain tissue homeostasis during development and adult life. Here, we review some of the major phenotypic characteristics of the hostile tumour microenvironment and the emerging roles of extracellular vesicles in these events.