Hypothalamic arcuate nucleus tyrosine hydroxylase neurons play orexigenic role in energy homeostasis.
Hypothalamic arcuate nucleus tyrosine hydroxylase neurons play orexigenic role in energy homeostasis.
复制标题
下丘脑弓状核酪氨酸羟化酶神经元在维持能量平衡中起促食欲作用。
DOI：
10.1038/nn.4372
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发表时间：
2016-10
影响因子：
25
通讯作者：
van den Pol AN
中科院分区：
文献类型：
--
作者：
Zhang X;van den Pol AN
能量平衡、食物摄入和体重都由特定的脑回路调节。在这里，我们介绍一个意想不到的神经元，酪氨酸羟化酶（TH）神经元的弓状核（ARC），我们表明，使食欲的贡献。小鼠ARC TH神经元的光遗传刺激增加食物摄入;衰减发射器释放降低体重。光遗传刺激ARC TH细胞通过突触机制抑制前阿黑皮素（POMC）神经元。ARC TH细胞投射到下丘脑室旁核; ARC TH轴突的光遗传学刺激通过多巴胺和GABA共释放抑制室旁核神经元。多巴胺兴奋食欲神经元合成刺豚鼠相关肽和神经肽Y，但抑制食欲神经元合成POMC，确定通过全细胞记录。食物剥夺增加ARC TH神经元c-fos表达和峰电位频率。肠肽ghrelin引起直接兴奋效应，表明这些神经元监测代谢线索。总之，这些数据支持ARC TH细胞在能量稳态中发挥未被认识和有影响力的积极作用的观点。
Energy homeostasis, food intake, and body weight are regulated by specific brain circuits. Here we introduce an unexpected neuron, the tyrosine hydroxylase (TH) neuron of the arcuate nucleus (ARC), that we show makes an orexigenic contribution. Optogenetic stimulation of mouse ARC TH neurons increased food intake; attenuating transmitter release reduced body weight. Optogenetic stimulation of ARC TH cells inhibited pro-opiomelanocortin (POMC) neurons through synaptic mechanisms. ARC TH cells project to the hypothalamic paraventricular nucleus; optogenetic stimulation of ARC TH axons inhibited paraventricular nucleus neurons by dopamine and GABA co-release. Dopamine excited orexigenic neurons that synthesize agouti-related peptide and neuropeptide Y but inhibited anorexigenic neurons that synthesize POMC, as determined by whole cell recording. Food deprivation increased c-fos expression and spike frequency in ARC TH neurons. The gut peptide ghrelin evoked direct excitatory effects, suggesting these neurons monitor metabolic cues. Together these data support the view that ARC TH cells play an unrecognized and influential positive role in energy homeostasis.
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影响因子：
3.4
作者：
Lin, John Y.;Lin, Michael Z.;Tsien, Roger Y.
通讯作者：
Tsien, Roger Y.
影响因子：
15.9
作者：
Abizaid, Alfonso;Liu, Zhong-Wu;Horvath, Tamas L.
通讯作者：
Horvath, Tamas L.
DOI：
10.1177/0269216307087148
发表时间：
2008-03-01
期刊：
Journal of psychopharmacology (Oxford, England)
影响因子：
--
作者：
Fitzgerald, Peter;Dinan, Timothy G
通讯作者：
Dinan, Timothy G
刺激性室室核向AGRP神经元电路，驱动饥饿。
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
48
作者：
Fenno, Lief E.;Mattis, Joanna;Ramakrishnan, Charu;Hyun, Minsuk;Lee, Soo Yeun;He, Miao;Tucciarone, Jason;Selimbeyoglu, Aslihan;Berndt, Andre;Grosenick, Logan;Zalocusky, Kelly A.;Bernstein, Hannah;Swanson, Haley;Perry, Chelsey;Diester, Ilka;Boyce, Frederick M.;Bass, Caroline E.;Neve, Rachael;Huang, Z. Josh;Deisseroth, Karl
通讯作者：
Deisseroth, Karl