Motor Responses to Sudden Limb Displacements in Primates with Specific CNS Lesions and in Human Patients with Motor System Disorders
Motor Responses to Sudden Limb Displacements in Primates with Specific CNS Lesions and in Human Patients with Motor System Disorders
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DOI：
10.1017/s0317167100020382
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发表时间：
1975-08
期刊：
影响因子：
--
通讯作者：
R. Lee;W. Tatton
中科院分区：
文献类型：
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作者：
R. Lee;W. Tatton
摘要：通过记录人类和猴子上肢突然位移的肌电图反应，使用精密扭矩电机产生阶跃负载变化，研究了运动控制的中央反馈路径。正常人类受试者表现出三种短潜伏期肌电图反应（M1、M2和M3），这似乎与从受过训练的猴子记录的那些相对应。 M2 和 M3 分量被认为代表脊髓上通路的反馈，当受试者被指示主动补偿负荷变化时，M2 和 M3 分量显着增加。患有强直的帕金森病患者表现出在 M2 和 M3 反应间隔期间反馈显着增加的证据，并且似乎失去了根据正在执行的运动任务调节反馈的能力。参考最近对灵长类动物运动控制机制的研究对结果进行了讨论，并提出了帕金森僵硬基础的初步模型。
SUMMARY: Central feedback pathways for motor control were studied by recording EMG responses to sudden upper limb displacements in humans and monkeys using a precision torque motor to generate step load changes. Normal human subjects showed three short-latency EMG responses (Ml, M2 and M3) which appear to correspond to those recorded from trained monkeys. The M2 and M3 components, thought to represent feedback in supraspinal pathways, were significantly increased when the subjects were instructed to actively compensate for the load changes. Parkinsonian patients with rigidity showed evidence of markedly increased feedback over the interval for the M2 and M3 responses and appeared to have lost the ability to modulate feedback according to the motor task being performed. The results are discussed with reference to recent research on motor control mechanisms in primates and a tentative model for the basis of Parkinsonian rigidity is proposed.