EMBRYONIC TISSUE MORPHOGENESIS MODELED BY FEM
EMBRYONIC TISSUE MORPHOGENESIS MODELED BY FEM
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DOI：
10.1115/1.2895713
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发表时间：
1994-05-01
影响因子：
1.7
通讯作者：
CLAUSI, DA
中科院分区：
文献类型：
--
作者：
BRODLAND, GW;CLAUSI, DA
本文提出了一种模拟胚胎组织形态发生行为的三维大应变有限元法。它被用来研究内陷、神经管形态发生、收缩波传播和机械图案形成等方面。模拟结果表明，图案的间距和形状所产生的某些形态发生的运动在上皮片仅轻微依赖于这些表的材料的属性。神经管闭合的模拟表明，许多实验观察到的功能，可以产生的顶端微丝束单独收缩。某些力系在力学上是等效的，某些变形模式是等效的，这对从模拟中可以推断出的内容设置了实际限制。
A three-dimensional, large-strain finite element formulation for the simulation of morphogenetic behaviors in embryonic tissues is presented. It is used to investigate aspects of invagination, neural tube morphogenesis, contraction wave propagation and mechanical pattern formation. The simulations show that the spacing of patterns and the shapes produced by certain morphogenetic movements in epithelial sheets depend only slightly on the properties of the materials which underlie these sheets. Simulations of neural tube closure show that numerous, experimentally-observed features can be produced by contraction of apical microfilament bundles alone. That certain systems of forces are mechanically equivalent and that certain patterns of deformations are equivalent set practical limits on what can be inferred from the simulations.