Evaluation of body Computed Tomography-determined sarcopenia in breast cancer patients and clinical outcomes: A systematic review.
Evaluation of body Computed Tomography-determined sarcopenia in breast cancer patients and clinical outcomes: A systematic review.
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DOI：
10.1016/j.ctarc.2019.100154
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发表时间：
2019-01-01
影响因子：
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通讯作者：
Tagliafico, Alberto Stefano
中科院分区：
文献类型：
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作者：
Rossi, Federica;Valdora, Francesca;Tagliafico, Alberto Stefano
目的：在多种恶性疾病中，肌肉量减少一直被认为是预后不良的因素。然而，评估乳腺癌患者CT检查结果与预后之间关系的研究报道了不同的结果。因此，本研究的目的是对目前关于乳腺癌患者体部CT确定的石棺减少的评价的文献进行系统的综述，重点是与结果值的相关性。方法：两位评价者独立评价了主要医学图书馆截至2019年4月24日的所有关于乳腺癌女性CT确定的石棺减少的研究。用于数据库搜索的关键词是：“石棺减少症”或“肌肉”或“肌肉重量”或“身体成分”和“乳腺肿瘤”或“乳腺癌”和“计算机断层扫描”。结果：在确定的n- = 研究中，共有n- = 15篇文章纳入系统综述。在所有研究中，在CT上第三腰椎(L3)水平对骨质疏松症进行评估；n = 14/15研究为回顾性研究。N = 13/15研究评估了骨质疏松症对临床结果的影响。在这些研究中，n = 8/13研究得出结论：骨肉减少是乳腺癌预后不良的重要危险因素，n = 5/13研究得出结论身体成分改变与预后不良无关。结论：大多数研究得出结论，CT评估的骨肉减少是乳腺癌患者重要的预后危险因素。需要高质量的前瞻性研究来强有力地确认和评估石棺减少对CT和乳腺癌预后的影响。
PURPOSE: Sarcopenia has been considered a poor prognostic factor in various malignant diseases. However, the studies that evaluated the association between CT-determined sarcopenia and outcome in breast cancer patients reported different results. Therefore, the aim of the present study is to perform a systematic review of the current literature on the evaluation of body CT-determined sarcopenia in breast cancer patients, focusing on the correlation with outcome values.METHODS: Two reviewers evaluated independently all studies dealing with CT-determined sarcopenia in breast cancer women from major medical libraries up to 24 April 2019. The keywords used for database searching were: "sarcopenia" or "muscles" or "muscle weight" or "body composition" and "breast neoplasms" or "breast cancer" and "computed tomography". Studies reporting clinical outcome values were finally compared.RESULTS: Of the n = 191 studies identified, a total of n = 15 articles were included in the systematic review. In all studies, sarcopenia was assessed at the level of the third lumbar vertebra (L3) on CT; n = 14/15 studies were retrospective. N = 13/15 studies evaluated the impact of sarcopenia on clinical outcomes. Among these studies, n = 8/13 studies concluded that sarcopenia is an important risk factor for poor prognosis in breast cancer and n = 5/13 studies concluded that body composition changes are not associated with poor prognosis.CONCLUSIONS: Most studies concluded that sarcopenia assessed on CT is an important prognostic risk factor in breast cancer patients. High-quality prospective studies to strongly confirm and assess the impact of sarcopenia evaluated on CT and breast cancer outcome are needed.