Atypical embryonic synapses fail to regenerate in adulthood.
Atypical embryonic synapses fail to regenerate in adulthood.
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非典型胚胎突触在成年后无法再生。
DOI：
10.1002/cne.21508
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
Modney,BarbaraK
中科院分区：
文献类型：
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作者：
Kloos,AnneD;Muller,KennethJ;Modney,BarbaraK
成年动物中枢神经系统(CNS)损伤后的功能恢复可能依赖于发育过程中精确连接模式的重建。当神经系统在胚胎发育过程中受到损伤时，功能恢复可能涉及形成非典型连接。这种非典型突触能否在成人体内再生，尤其是在以修复能力著称的神经系统中？当水蚤一个节段性神经节中的S中间神经元在发育过程中被杀死时，相邻的两个S细胞将轴突延伸到神经节内，并通过与被杀死的S细胞通常的突触靶点进行电突触来恢复功能。尽管成年的S细胞轴突可以可靠地再生它们通常的突触连接，但在胚胎损伤后诱导的新突触在成人中无法再生。在这些制备中，切断的S细胞轴突没有到达失神经的神经节，而是生长在离它很近的地方，与生长所需的距离无关。因此，胚胎中允许异常但功能连接的发育变化并不会导致成年患者轴突生长和随后的突触再生能力发生类似的变化。J.Comp.神经。505：404-411,2007。©2007 Wiley-Liss Inc.
Functional recovery following central nervous system (CNS) injury in adult animals may depend on the reestablishment of the precise pattern of connections made during development. When the nervous system is injured during embryonic development, functional recovery may involve the formation of atypical connections. Can such atypical synapses regenerate in adults, particularly in a nervous system known for its capacity for repair? When the S interneuron in one segmental ganglion of the leechHirudois killed during development, two neighboring S cells extend their axons into the ganglion and restore function by making electrical synapses with the usual synaptic targets of the killed S cell. Although adult S‐cell axons reliably regenerated their usual synaptic connections, the novel synapses induced following embryonic injury failed to regenerate in adults. In these preparations severed S‐cell axons did not reach the denervated ganglion but grew close to it, independent of the distance required to grow. Thus, the developmental changes that permit aberrant but functional connections in embryos do not lead to a similar change in the capacity for axon growth and subsequent synapse regeneration in adults. J. Comp. Neurol. 505:404–411, 2007. © 2007 Wiley‐Liss, Inc.