Ranges of Cervical Intervertebral Disc Deformation During an In Vivo Dynamic Flexion-Extension of the Neck
Ranges of Cervical Intervertebral Disc Deformation During an In Vivo Dynamic Flexion-Extension of the Neck
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DOI：
10.1115/1.4036311
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发表时间：
2017-06-01
影响因子：
1.7
通讯作者：
Cha, Thomas D.
中科院分区：
文献类型：
--
作者：
Yu, Yan;Mao, Haiqing;Cha, Thomas D.
虽然负载异常被广泛认为是导致颈椎间盘疾病的原因，但活体颈盘在动态颈椎运动过程中的变形还没有得到很好的描述。这项研究调查了在活体功能性颈椎屈伸过程中颈椎间盘变形的范围。使用双荧光成像系统(DFIS)和基于磁共振成像(MRI)的三维(3D)建模技术对10名无症状的人体受试者进行了测试。根据各椎间节段(C3/4、C4/5、C5/6和C6/7)上、下终板之间的空间几何形状的变化来确定整个椎间盘的变形。分析每个椎间盘的5个点(前、中、后、左、右)，以检查椎间盘的变形分布。结果表明，在颈椎功能性最大屈伸之间，关节盘前点发生了较大的拉伸/压缩变形和剪切变形变化。较高水平的盘经历了较大范围的盘变形。各节段后部各节段的变形范围无明显差异。结果表明，除C6/7外，各节段的变形量均随节段的变化而变化，除C6/7节段外，其他节段前部的变形量均大于中央区和后侧区。本研究获得的数据可作为了解颈椎间盘生物力学和研究间盘疾病的生物力学病因的基础知识。这些数据也可以为颈椎运动保护手术的发展提供见解。
While abnormal loading is widely believed to cause cervical spine disc diseases, in vivo cervical disc deformation during dynamic neck motion has not been well delineated. This study investigated the range of cervical disc deformation during an in vivo functional flexion-extension of the neck. Ten asymptomatic human subjects were tested using a combined dual fluoroscopic imaging system (DFIS) and magnetic resonance imaging (MRI)-based three-dimensional (3D) modeling technique. Overall disc deformation was determined using the changes of the space geometry between upper and lower endplates of each intervertebral segment (C3/4, C4/5, C5/6, and C6/7). Five points (anterior, center, posterior, left, and right) of each disc were analyzed to examine the disc deformation distributions. The data indicated that between the functional maximum flexion and extension of the neck, the anterior points of the discs experienced large changes of distraction/compression deformation and shear deformation. The higher level discs experienced higher ranges of disc deformation. No significant difference was found in deformation ranges at posterior points of all the discs. The data indicated that the range of disc deformation is disc level dependent and the anterior region experienced larger changes of deformation than the center and posterior regions, except for the C6/7 disc. The data obtained from this study could serve as baseline knowledge for the understanding of the cervical spine disc biomechanics and for investigation of the biomechanical etiology of disc diseases. These data could also provide insights for development of motion preservation surgeries for cervical spine.