Validation study of the UICC TNM classification of malignant tumors, seventh edition, in breast cancer
Validation study of the UICC TNM classification of malignant tumors, seventh edition, in breast cancer
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DOI：
10.1007/s12282-013-0453-7
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发表时间：
2014-11-01
期刊：
影响因子：
4
通讯作者：
Akiyama, Futoshi
中科院分区：
文献类型：
--
作者：
Uehiro, Natsue;Horii, Rie;Akiyama, Futoshi
国际反腐败联盟的TNM分类在第七版中进行了修订。关于乳腺癌的主要变化是T0或T1 N1 miM 0患者分期的变化。为验证第七版TNM分期在乳腺癌中的适用性，对我院1996年收治的416例乳腺癌患者按第六版和第七版TNM分期进行分期，并进行比较，第六版病例分布为0期，56例（13.5%）; I期158例（38.0%）; II期130例[A，102; B，28]例（31.2 [A，24.5; B，6.7] %）; III期72例[A，31; B，8; C，33]例（17.3 [A，7.5; B，1.9; C，7.9] %）。根据第七版，20例患者（占第六版IIA病例的19.6%）的分期从IIA降至IB。根据第6版，10年总生存率为0期91.1%; I期88.6%; II期80.8%; III期63.9%;根据第7版，10年总生存率为0期91.1%; I期88.8%; II期79.1%; III期63.9%。虽然根据第六版，0至II期的生存率之间没有显著差异，但根据第七版，I期和II期之间存在显著差异（p = 0.026）。从预后的角度来看，最新修订的TNM分类适用于乳腺癌。
The TNM classification of the Unio Internationalis Contra Cancrum was revised for the seventh edition. The major change concerning breast cancer is a change in the stages for patients with T0 or T1N1miM0. In the present study, the seventh edition of the TNM classification was validated in breast cancer.The stages of 416 breast cancer patients, treated at our hospital in 1996, were classified according to the TNM classification, sixth and seventh editions, and their prognoses were compared.Case distribution using the sixth edition was stage 0, 56 cases (13.5 %); stage I, 158 cases (38.0 %); stage II, 130 [A, 102; B, 28] cases (31.2 [A, 24.5; B, 6.7] %); and stage III, 72 [A, 31; B, 8; C, 33] cases (17.3 [A, 7.5; B, 1.9; C, 7.9] %). According to the seventh edition, the stages for 20 patients, accounting for 19.6 % of IIA cases according to the sixth edition, decreased from IIA to IB. The 10-year overall survivals were stage 0, 91.1 %; stage I, 88.6 %; stage II, 80.8 %; and stage III, 63.9 % according to the sixth edition; and stage 0, 91.1 %; stage I, 88.8 %; stage II, 79.1 %; and stage III, 63.9 % according to the seventh edition. Although no significant differences were seen among the survival rates for stages 0 to II according to the sixth edition, there was a significant difference between stage I and II according to the seventh edition (p = 0.026).The latest revision of the TNM classification is appropriate for breast cancer from the perspective of prognosis.