Innate and adaptive immune system cells implicated in tendon healing and disease.
Innate and adaptive immune system cells implicated in tendon healing and disease.
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DOI：
10.22203/ecm.v043a05
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发表时间：
2022-02-18
影响因子：
3.1
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中科院分区：
文献类型：
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肌腱在肌肉骨骼系统中发挥着至关重要的作用，它将肌肉与骨骼结合在一起，并使力量传递成为可能。这些组织的损伤或退化会导致结构和功能受损，尽管进行了手术干预，但这种情况往往会持续下去。虽然免疫反应和炎症是肌腱愈合和疾病进展的重要驱动因素，但在肌腱领域，可能调节这些过程的不同免疫细胞类型的研究相对较少。到目前为止，大多数研究都集中在巨噬细胞上，但新出现的研究表明，其他类型的免疫细胞也可能通过调节免疫环境或通过与常驻肌腱细胞直接相互作用而在肌腱愈合中发挥作用。在这里，我们在动物损伤模型、人类临床样本或体外实验的背景下，综合有关先天性和获得性免疫细胞与肌腱愈合或疾病有关的文献。
Tendons perform a critical function in the musculoskeletal system by integrating muscle with skeleton and enabling force transmission. Damage or degeneration of these tissues leads to impaired structure and function, which often persist despite surgical intervention. While the immune response and inflammation are important drivers of both tendon healing and disease progression, there have been relatively few studies of the diverse immune cell types that may regulate these processes in the tendon field. To date, most of the studies have focused on macrophages, but emerging research indicate that other immune cell types may also play a role in tendon healing, either by regulation of the immune environment or through direct interactions with resident tenocytes. Here, we synthesize the literature on innate and adaptive immune cells that have been implicated in tendon healing or disease, in the context of animal injury models, human clinical samples, or in vitro experimentation.