Interleukin-6 as an independent predictor of future cardiovascular events in high-risk Japanese patients: Comparison with C-reactive protein
Interleukin-6 as an independent predictor of future cardiovascular events in high-risk Japanese patients: Comparison with C-reactive protein
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DOI：
10.1016/j.cyto.2010.12.005
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发表时间：
2011-03-01
期刊：
影响因子：
3.8
通讯作者：
Kawano, Yuhei
中科院分区：
文献类型：
--
作者：
Nishida, Hidenori;Horio, Takeshi;Kawano, Yuhei
炎症与动脉粥样硬化血管病变的发展相关，一些炎症参数被用作心血管（CV）风险标记。本研究旨在评估白细胞介素 (IL)-6 对未来心血管事件的预测能力。在 121 名患有多种 CV 危险因素和/或疾病的日本患者中，测量了 IL-6 和超敏 C 反应蛋白 (hs-CRP) 的血清浓度。在基线评估后的随访期间（平均 2.9 年），50 名患者新经历了心血管事件，如中风/短暂性脑缺血发作 (n = 10)、心力衰竭住院 (n = 6)、急性冠脉综合征 (n = 7)、冠状动脉疾病血运重建 (n = 15) 和外周动脉疾病 (n = 12)。发生心血管事件的患者的血清 IL-6 水平显着高于无事件受试者（3.9 +/- 2.6 和 3.0 +/- 2.2 pg/mL，P = 0.04），但 hs-CRP 没有。当根据IL-6基础水平三分位数（<1.85、1.85-3.77和≥3.77 pg/mL）将患者分为三组时，Kaplan-Meier法的累积无事件率随着基础IL-6水平的增加而降低（IL-6最低、中间和最高三分位数分别为65%、50%和19%；对数秩检验，P = 0.002）。通过单变量 Cox 回归分析，既往 CV 疾病、肌酐清除率和血清 IL-6 水平与随访期间的 CV 事件显着相关。在这些可能的预测因子中，IL-6 的最高三分位数仅是多变量分析中发病率的独立决定因素（风险比 2.80 与最低三分位数，P = 0.006）。这些发现表明，IL-6 是日本高危患者未来 CV 事件的强大独立预测因子，表明其预测价值优于 hs-CRP。 (c) 2010 Elsevier Ltd. 保留所有权利。
Inflammation is associated with the development of atherosclerotic vascular lesions and some inflammatory parameters are used as cardiovascular (CV) risk markers. The present study was designed to assess the predictive power of interleukin (IL)-6 for future CV events. In 121 Japanese patients with multiple CV risk factors and/or disease, serum concentrations of IL-6 and high sensitive C-reactive protein (hs-CRP) were measured. During follow-up periods (mean, 2.9 years) after the baseline assessment, 50 patients newly experienced CV events such as stroke/transient ischemic attack (n = 10), heart failure hospitalization (n = 6), acute coronary syndrome (n = 7), and revascularization for coronary artery disease (n = 15) and peripheral arterial disease (n = 12). The serum level of IL-6, but not hs-CRP, was significantly higher in patients who had CV events than in event-free subjects (3.9 +/- 2.6 and 3.0 +/- 2.2 pg/mL, P = 0.04). When the patients were divided into three groups by tertiles of basal levels of IL-6 (< 1.85, 1.85-3.77, and >= 3.77 pg/mL), cumulative event-free rates by the Kaplan-Meier method were decreased according to the increase in basal IL-6 levels (65%, 50%, and 19% in the lowest, middle, and highest tertiles of IL-6, respectively; log-rank test, P = 0.002). By univariate Cox regression analysis, previous CV disease, creatinine clearance, and serum IL-6 levels were significantly associated with CV events during follow-up. Among these possible predictors, the highest tertile of IL-6 was only an independent determinant for the morbidity in the multivariate analysis (hazard ratio 2.80 vs. lowest tertile, P = 0.006). These findings indicate that IL-6 is a powerful independent predictor of future CV events in high-risk Japanese patients, suggesting its predictive value is superior to that of hs-CRP. (c) 2010 Elsevier Ltd. All rights reserved.