Mesothelin and GPR30 Staining Among a Spectrum of Pancreatic Epithelial Neoplasms
Mesothelin and GPR30 Staining Among a Spectrum of Pancreatic Epithelial Neoplasms
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DOI：
10.1177/1066896911409575
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发表时间：
2011-10-01
影响因子：
1.2
通讯作者：
Prossnitz, Eric R.
中科院分区：
文献类型：
--
作者：
Glass, Joseph P.;Parasher, Gulshan;Prossnitz, Eric R.
前言：本研究试图对胰腺病理中的间质蛋白和GPR30/雌激素受体(ER)染色进行研究。材料和方法：采用免疫组织化学方法检测不同类型胰腺病变组织中间皮蛋白、GPR30和ER的表达。结果：42例腺癌中24例(57%)表达间硫蛋白，16例非癌组织中0例(0%)表达，差异有统计学意义(P=0.0000784)。39例腺癌中35例(90%)表达GPR30，15例非癌组织中仅4例(27%)表达GPR30(p=0.0000036)。除1例粘液性囊性肿瘤间质染色外，无ER染色。37例腺癌细针抽吸物中有27例(73%)间皮蛋白阳性。讨论：GPR30对胰腺癌更敏感，但特异性较差。在大多数腺癌细针抽吸物中均可检测到间充质蛋白。在胰腺病变中很少检测到ER。
Introduction: Our study attempts to characterize mesothelin and GPR30 / estrogen receptor (ER) staining in pancreatic pathology. Materials and Methods: Immunohistochemical staining for mesothelin, GPR30, and ER was performed on a variety of pancreatic lesions. Results: 24 of 42 (57%) adenocarcinomas stained for mesothelin, while 0 of 16 non-carcinomas (0%) stained (p = 0.0000784). 35 of 39 (90%) adenocarcinomas stained for GPR30, while only 4 of 15 (27%) non-carcinomas stained (p = 0.0000036). Apart from stromal staining in one case of mucinous cystic neoplasm, no cases stained for ER. 27 of 37 (73%) adenocarcinoma fine needle aspirates were positive for mesothelin. Discussion: GPR30 is more sensitive, but less specific than mesothelin for pancreatic adenocarcinoma. Mesothelin is detected in most adenocarcinoma fine needle aspirates. ER is rarely detected in pancreatic lesions.