Non-Gaussian Diffusion Imaging Shows Brain Myelin and Axonal Changes in Obstructive Sleep Apnea.
Non-Gaussian Diffusion Imaging Shows Brain Myelin and Axonal Changes in Obstructive Sleep Apnea.
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DOI：
10.1097/rct.0000000000000537
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发表时间：
2017
影响因子：
1.3
通讯作者：
Kumar R
中科院分区：
文献类型：
--
作者：
Tummala S;Roy B;Vig R;Park B;Kang DW;Woo MA;Aysola R;Harper RM;Kumar R
阻塞性睡眠呼吸暂停 (OSA) 伴随着调节自主神经、认知和情绪功能的大脑区域的变化，这些变化最初是通过基于高斯的扩散张量成像测量来检查的，但可以通过非高斯测量来更好地评估。我们的目的是使用轴向 (AK) 和径向峰度 (RK) 测量来评估 OSA 中的轴突和髓磷脂变化。我们从 22 个 OSA 和 26 个对照中获取了 DKI 数据；使用 ANCOVA 计算、标准化、平滑并在组之间比较 AK 和 RK 图。 AK 增加，表明轴突发生变化，出现在岛叶、海马、杏仁核、背外侧脑桥和小脑脚中，并且显示出比先前发现的损伤更多的轴突损伤。较高的 RK 显示髓磷脂变化，出现在海马、杏仁核、颞叶和额叶、岛叶、脑桥中线和小脑脚，并且显示出比先前发现的损伤更广泛的髓磷脂损伤。 AK 和 RK 测量显示与基于高斯的技术相比存在广泛的变化，表明峰度对损伤更加敏感。
Obstructive sleep apnea (OSA) is accompanied by brain changes in areas that regulate autonomic, cognitive, and mood functions, which were initially examined by Gaussian-based diffusion tensor imaging measures, but can be better assessed with non-Gaussian measures. We aimed to evaluate axonal and myelin changes in OSA using axial (AK) and radial kurtosis (RK) measures. We acquired DKI data from 22 OSA and 26 controls; AK and RK maps were calculated, normalized, smoothed, and compared between groups using ANCOVA. Increased AK, indicating axonal changes, emerged in the insula, hippocampus, amygdala, dorsolateral-pons, and cerebellar peduncles, and showed more axonal injury over previously-identified damage. Higher RK, showing myelin changes, appeared in the hippocampus, amygdala, temporal and frontal lobes, insula, midline-pons, and cerebellar peduncles, and showed more wide-spread myelin damage over previously-identified injury. AK and RK measures showed wide-spread changes over Gaussian-based techniques, suggesting more-sensitive nature of kurtoses to injury.