Polymer brushes that resist adsorption of model proteins: Design parameters
Polymer brushes that resist adsorption of model proteins: Design parameters
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DOI：
10.1021/la981356f
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发表时间：
1999-03-30
期刊：
影响因子：
3.9
通讯作者：
Halperin, A
中科院分区：
文献类型：
--
作者：
Halperin, A
模型蛋白质吸附到刷涂表面上可以通过两种模式发生。在表面的初级吸附，其中短程吸引力是占主导地位的，是重要的小蛋白质，并可能被抑制通过增加接枝密度。由于货车德瓦耳斯引力，二次吸附发生在刷的外边缘。大的杆状蛋白质可能以这种方式吸附。这种模式可以通过增加电刷厚度来抑制。模型蛋白质吸附的热力学和动力学被认为是在一个简单的分析理论区分不同的吸附机制的小和大的蛋白质。
The adsorption of model proteins onto brush-coated surfaces can occur via two modes. Primary adsorption at the surface, where short range attraction is dominant, is important for small proteins and may be repressed by increasing the grafting density. Secondary adsorption, due to van der Waals attraction, occurs at the outer edge of the brush. Large rodlike proteins are likely to adsorb in this fashion. This mode may be repressed by increasing the brush thickness. The thermodynamics and kinetics of adsorption of model proteins are considered within a simple analytical theory distinguishing between the different adsorption mechanisms of small and big proteins.