Comparison of Cysts in Red and Green Images for Diabetic Macular Edema.
Comparison of Cysts in Red and Green Images for Diabetic Macular Edema.
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糖尿病黄斑水肿的红色和绿色图像中囊肿的比较。
DOI：
10.1097/opx.0000000000001010
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发表时间：
2017-02
期刊：
影响因子：
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通讯作者：
Miura M
中科院分区：
文献类型：
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作者：
Alhamami MA;Elsner AE;Malinovsky VE;Clark CA;Haggerty BP;Ozawa GY;Cuadros JA;Baskaran K;Gast TJ;Litvin TV;Muller MS;Brahm SG;Young SB;Miura M
目的：探讨糖尿病黄斑水肿患者眼底图像的红色通道与绿色通道相比，是否能更好地显示糖尿病黄斑水肿的囊性病变，因为强调短波长光的彩色眼底影像筛查方法可能会遗漏有暗色眼底或外血视网膜屏障改变的患者的囊性病变。糖尿病视网膜病变的眼底图像被采集用于与永旺成像、EyePACS、加州大学伯克利分校和印第安纳大学的一项研究。有2047名未得到充分服务的成年糖尿病患者，其中超过90%的人自认为是非西班牙裔白人以外的种族/民族认同。使用佳能(Canon)非散瞳相机(日本东京)采集标称为45度的彩色眼底图像，然后由EyePACS认证的分级机进行分级。我们对14 8例黄斑中心凹中央15 0 0μm处有硬性渗出物的黄斑水肿患者进行了评估，其中13例黄斑囊样水肿患者有黄斑囊肿。年龄33~68岁。用定制的MatLab软件(Mathworks，Natick，MA)将彩色眼底图像分成红色、绿色和蓝色通道。分别在红色通道图像和绿色通道图像中对囊性或融合囊性肿块的直径进行量化。红色通道图像与标准全彩色图像的囊性鉴别结果完全一致。绿色通道图像的情况并非如此，在5例有深色眼底的病例中，绿色通道图像没有暴露出用标准全色图像可见的囊肿。红色通道的囊性变多，面积(733±604μm)大于绿色通道(349±433μm，P<0.006)。目前的眼底照相方法可能会漏诊囊肿，特别是在强调短波长光或眼底较暗的患者时。更长波长的技术可能会提高对囊性病变的检测，并提供更多关于糖尿病黄斑水肿或外血视网膜屏障早期阶段的信息。
To investigate whether cysts in diabetic macular edema are better visualized in the red channel of color fundus camera images, as compared with the green channel, because color fundus camera screening methods that emphasize short-wavelength light may miss cysts in patients with dark fundi or changes to outer blood retinal barrier. Fundus images for diabetic retinopathy photoscreening were acquired for a study with Aeon Imaging, EyePACS, University of California Berkeley, and Indiana University. There were 2047 underserved, adult diabetic patients, of whom over 90% self-identified as a racial/ethnic identify other than non-Hispanic white. Color fundus images at nominally 45 degrees were acquired with a Canon Cr-DGi non-mydriatic camera (Tokyo, Japan) then graded by an EyePACS certified grader. From the 148 patients graded to have clinically significant macular edema by the presence of hard exudates in the central 1500 μm of the fovea, we evaluated macular cysts in 13 patients with cystoid macular edema. Age ranged from 33 to 68 years. Color fundus images were split into red, green, and blue channels with custom Matlab software (Mathworks, Natick, MA). The diameter of a cyst or confluent cysts was quantified in the red-channel and green-channel images separately. Cyst identification gave complete agreement between red-channel images and the standard full-color images. This was not the case for green-channel images, which did not expose cysts visible with standard full-color images in five cases, who had dark fundi. Cysts appeared more numerous and covered a larger area in the red channel (733 ± 604 μm) than in the green channel (349 ± 433 μm, P < .006). Cysts may be underdetected with the present fundus camera methods, particularly when short-wavelength light is emphasized or in patients with dark fundi. Longer wavelength techniques may improve the detection of cysts and provide more information concerning the early stages of diabetic macular edema or the outer blood retinal barrier.