Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii
Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii
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DOI：
10.1021/np970445
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发表时间：
1998-06-01
影响因子：
5.1
通讯作者：
Lee, HK
中科院分区：
文献类型：
--
作者：
Jung, KY;Kim, DS;Lee, HK
为寻找血小板活化因子（PAF）拮抗剂，从中药厚朴（Magnolia fargesii）的花蕾中分离得到两个新的木脂素类化合物。它们的结构被鉴定为（2S，3R，4 R）-四氢-2-（3，4-二甲氧基苯基）-4-（3，4-二甲氧基苯甲酰基）-3-（羟甲基）呋喃（马格尼酮A，1）和（2S，3R，4 R）-四氢-2-（3，4，5-三甲氧基苯基）-4-（3，4-二甲氧基苯甲酰基）-3-（羟甲基）呋喃（马格尼酮B，2）。在[H-3]PAF受体结合试验中，Magnone A和B显示出对PAF的拮抗活性，IC 50值分别为3.8 x 10（-5）M和2.7 x 10（-5）M。
In a search for platelet-activating-factor (PAF) antagonists, two new lignan compounds were isolated from the Chinese crude drug shin-i, the flower buds of Magnolia fargesii. Their structures were elucidated as (2S,3R,4R)-tetrahydro-2-(3,4-dimethoxyphenyl)-4-(3,4-dimethoxybenzoyl)-3-(hydroxymethyl)furan (magnone A, 1) and (2S,3R,4R)-tetrahydro-2-(3,4,5-trimethoxyphenyl)-4-(3,4-dimethoxybenzoyl)-3-(hydroxymethyl)furan (magnone B, 2). Magnones A and B showed antagonistic activity against PAF in the [H-3]PAF receptor binding assay with the IC50 values of 3.8 x 10(-5) M and 2.7 x 10(-5) M, respectively.