A consensus approach to electrolytes and blood pressure. Could we all be right?
A consensus approach to electrolytes and blood pressure. Could we all be right?
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关于电解质和血压的共识方法。
DOI：
10.1161/01.hyp.17.1_suppl.i170
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
McCarron,DA
中科院分区：
文献类型：
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作者：
McCarron,DA
这篇评论阐述了这样一个假设，即特定电解质对血压调节的假定有益或有害影响实际上反映了这些阳离子和阴离子物种之间相互作用的高度综合反应。在此范例中，任何给定的电解质摄入对动脉压的影响将受到其他电解质同时消耗的影响。因此，人体对钠、钙和钾等营养素的单独操作的异质性血压反应可能部分取决于其他矿物质元素的膳食摄入是否充足。如果这一假设在这一领域的持续研究中得到验证，我们将有新的策略来改善人类的血压控制。例如，通过纠正钾或钙的饮食缺乏可能比限制饮食NaCl更有效地治疗某些人的“NaCl敏感性”。
This commentary sets forth the hypothesis that the putative beneficial or detrimental effects of specific electrolytes on blood pressure regulation in fact reflect highly integrated responses to interactions among these cationic and anionic species. In this paradigm, the impact of any given intake of an electrolyte on arterial pressure will be influenced by the concurrent consumption of other electrolytes. Thus, the heterogeneous blood pressure response in humans to isolated manipulations of nutrients such as sodium, calcium, and potassium may be determined, in part, by the adequacy of the dietary intake of other mineral elements. If this hypothesis is validated by continued research in this area, we would have new strategies available to improve blood pressure control in humans. For example, treatment of "NaCl sensitivity" in some humans might be more effectively approached by correcting dietary deficiencies of either potassium or calcium than by restricting dietary NaCl.