Longitudinal MRI Reveals Altered Trajectory of Brain Development during Childhood and Adolescence in Fetal Alcohol Spectrum Disorders
Longitudinal MRI Reveals Altered Trajectory of Brain Development during Childhood and Adolescence in Fetal Alcohol Spectrum Disorders
复制标题
DOI：
10.1523/jneurosci.5004-12.2013
复制
发表时间：
2013-06-12
影响因子：
5.3
通讯作者：
Beaulieu, Christian
中科院分区：
文献类型：
--
作者：
Treit, Sarah;Lebel, Catherine;Beaulieu, Christian
胎儿酒精谱系障碍（FASD）脑发育的扩散张量成像（DTI）显示了结构异常，但研究受到使用横断面设计的限制。纵向扫描可以提供关键的见解神经发育的轨迹在个人与这种常见的发育障碍。在这里，我们评估了17名FASD参与者和27名5-15岁的对照者的人体样本的连续DTI和T1加权容积MRI，他们每个人都接受了2-3次扫描，间隔2-4年（共92次扫描）。两组扫描之间观察到各向异性分数增加和平均扩散率（MD）降低，与典型发育的预期变化一致，但混合模型分析显示三个主要白色物质束（上级纵束和上级和下额枕束）存在显著的年龄-组相互作用。这些发现表明这些额叶联合束的发育进展发生了变化，FASD组在扫描之间明显显示MD减少。在FASD组中，Delta MD与阅读和接受性词汇相关，在两次扫描之间，上级额枕束和上级纵束中MD的急剧下降与语言评分的更大改善相关。容量分析显示，FASD组的全脑、白色、皮质灰质和深部灰质体积减少，且与年龄相关的体积增加较少，但年龄与组间的相互作用不显著。纵向DTI显示FASD儿童期和青春期的白色发育延迟，这可能是这一关键时期持续或恶化的行为和认知缺陷的基础。
Diffusion tensor imaging (DTI) of brain development in fetal alcohol spectrum disorders (FASD) has revealed structural abnormalities, but studies have been limited by the use of cross-sectional designs. Longitudinal scans can provide key insights into trajectories of neurodevelopment within individuals with this common developmental disorder. Here we evaluate serial DTI and T1-weighted volumetric MRI in a human sample of 17 participants with FASD and 27 controls aged 5-15 years who underwent 2-3 scans each, similar to 2-4 years apart (92 scans total). Increases of fractional anisotropy and decreases of mean diffusivity (MD) were observed between scans for both groups, in keeping with changes expected of typical development, but mixed-models analysis revealed significant age-by-group interactions for three major white matter tracts: superior longitudinal fasciculus and superior and inferior fronto-occipital fasciculus. These findings indicate altered developmental progression in these frontal-association tracts, with the FASD group notably showing greater reduction of MD between scans. Delta MD is shown to correlate with reading and receptive vocabulary in the FASD group, with steeper decreases of MD in the superior fronto-occipital fasciculus and superior longitudinal fasciculus between scans correlating with greater improvement in language scores. Volumetric analysis revealed reduced total brain, white, cortical gray, and deep gray matter volumes and fewer significant age-related volume increases in the FASD group, although age-by-group interactions were not significant. Longitudinal DTI indicates delayed white matter development during childhood and adolescence in FASD, which may underlie persistent or worsening behavioral and cognitive deficits during this critical period.