Genotype x environment interaction in psychopathology: Fact or artifact?
Genotype x environment interaction in psychopathology: Fact or artifact?
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DOI：
10.1375/183242706776403073
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发表时间：
2006-02-01
影响因子：
0.9
通讯作者：
Eaves, LJ
中科院分区：
文献类型：
--
作者：
Eaves, LJ
最近的研究声称检测候选基因和特定环境因素之间的相互作用（基因型x环境相互作用，G x E）在精神疾病的易感性。本研究的目的是检查可能的文物，可以解释广泛宣传的结果。候选基因和测量的环境对疾病的易感性的加性效应进行了模拟的模型下，允许在有条件的基因型和环境的责任分布的混合物。模拟负债在阈值处被二分以反映疾病的诊断。通过标准统计方法分析多个模拟数据块，以测试基因和环境对结果的主要影响和相互作用。这项研究的主要成果是模拟负债和诊断的严重抑郁症和反社会行为。通过逻辑回归分析的二分数据经常检测到显着的G × E的相互作用，即使没有责任。因此，有理由质疑已发表研究结果的生物学意义。
Recent studies have claimed to detect interaction between candidate genes and specific environmental factors (Genotype x Environment interaction, G x E) in susceptibility to psychiatric disorder. The objective of the present study was to examine possible artifacts that could explain widely publicized findings. The additive effects of candidate genes and measured environment on liability to disorder were simulated under a model that allowed for mixture of distributions in liability conditional on genotype and environment. Simulated liabilities were dichotomized at a threshold value to reflect diagnosis of disorder. Multiple blocks of simulated data were analyzed by standard statistical methods to test for the main effects and interactions of genes and environment on outcome. The main outcome of this study was simulated liabilities and diagnoses of major depression and antisocial behavior. Analysis of the dichotomized data by logistic regression frequently detected significant G x E interaction even though none was present for liability. There is therefore reason to question the biological significance of published findings.