Elevated oleic acid serum concentrations in patients suffering from alcohol dependence.
Elevated oleic acid serum concentrations in patients suffering from alcohol dependence.
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DOI：
10.1186/2049-9256-1-13
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Irmisch G
中科院分区：
文献类型：
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作者：
Teubert A;Thome J;Büttner A;Richter J;Irmisch G
酒精引起的脑萎缩和脂肪肝等损害与脂质代谢紊乱密切相关。在动物模型中，慢性饮酒与各种器官和细胞中脂肪酸（FA）组成变化之间的联系是众所周知的，并且有迹象表明这种现象可能与酒精成瘾相关的行为改变有关，例如渴望。然而，乙醇对分泌型FA的影响迄今为止还没有研究。因此，在这项研究中，我们的目的是调查是否有一个显着的变化，血清FA组成的患者患有酒精依赖。我们比较了治疗（戒毒）前后的患者与没有成瘾的对照组。年龄，酒精使用的持续时间和强度以及生活方式的作用被考虑在内。血清FA测定73名男性酒精依赖患者之前和之后的酒精戒断在住院设置。另外，在该组中，45例患者与45名健康男性志愿者匹配作为对照。我们发现，在FA组成的显着差异之前和之后的解毒，以及患者和对照组之间。解毒后，这些值向健康对照组的值变化。在急性酒精使用期间的主要发现是油酸浓度高于亚油酸浓度水平。升高的油酸/亚油酸比例似乎是急性酒精使用的状态标记，并且可能是解毒过程中的相关性状标记，并且可能是随后的治疗措施。这项初步研究的结果需要在一项包括女性患者的更大规模研究中重复。此外，需要确定这种潜在生物标志物的特异性。
Alcohol-induced damages such as brain atrophy and fatty liver are closely related to a disturbed lipid metabolism. In animal models, a linkage between chronic alcohol consumption and changes in fatty acid (FA) composition in various organs and cells is well known and there is some indication that this phenomenon could be linked to behavioural alterations associated with alcohol addiction such as craving. However, the influence of ethanol on secretory FA has not been investigated so far. In this study, we therefore aimed at investigating whether there is a significant change of serum FA composition in patients suffering from alcohol dependence. We compared patients before and after treatment (detoxication) with control individuals who did not suffer from addiction. The roles of age, the duration and intensity of alcohol use and lifestyles were considered. Serum FA was measured in 73 male ethanol dependent patients before and after alcohol withdrawal in an in-patient setting. Additionally, of this group, 45 patients were matched with 45 healthy male volunteers as controls. We found significant differences in the FA composition before and after detoxication as well as between patients and controls. After detoxication, the values changed towards the ones in healthy controls. The main finding during acute alcohol use was an increased oleic acid concentration above the level of the linoleic acid concentration. An elevated oleic/linoleic acid ratio seems to be a state marker for acute alcohol use and may be a relevant trait marker during detoxification and possibly the subsequent therapeutic measures. The results of this pilot study need to be replicated in a larger study also including female patients. Further, the specificity of this potential biomarker needs to be determined.