Regulation of food intake by metabolic fuels in white-crowned sparrows.
Regulation of food intake by metabolic fuels in white-crowned sparrows.
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白冠麻雀代谢燃料对食物摄入的调节。
DOI：
10.1152/ajpregu.1995.269.6.r1462
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Woods,SC
中科院分区：
文献类型：
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作者：
Boswell,T;Richardson,RD;Seeley,RJ;Ramenofsky,M;Wingfield,JC;Friedman,MI;Woods,SC
候鸟依靠增加脂肪储存和脂肪酸利用率来满足能量消耗的季节性变化，从而增加迁徙前的食物摄入量和脂肪储存。为了确定它们的摄食行为是否对碳水化合物和/或脂肪酸的利用敏感，对维持短日照（9L15D）的白冠麻雀腹膜内注射2-脱氧-D-葡萄糖（2-DG）或2,5-脱水-D-甘露醇（2,5-AM）。低剂量的 2-DG（25 或 50 mg/kg）对食物摄入没有影响，而较高剂量（100 或 300 mg/kg）则在 1 和 2 小时后显着抑制进食。没有剂量的 2-DG 会增加膳食量。同样，低剂量的 2,5-AM（25、50 或 100 毫克/千克）对食物摄入没有影响，而较高剂量（300 和 600 毫克/千克）则显着抑制摄入。这些数据表明，碳水化合物代谢的降低不会引起该物种的摄食。重要的是，这些药物以及胰岛素和胰高血糖素被证明可以增加血浆脂肪酸并减少进食。腹腔注射三丁酸甘油酯（100、300、600或2,000 mg/kg）或甘油（300、450和600 mg/kg）也显着抑制这些鸡的60分钟和120分钟食物摄入量，剂量依赖性，而等摩尔葡萄糖（1,200 mg/kg）没有效果。我们得出的结论是，白冠麻雀的摄食对碳水化合物代谢的操作没有反应，并且在增加血浆脂质的操作后会减少。
Migratory birds rely on increased fat storage and fatty acid utilization to meet seasonal changes of energy expenditure and as a result increase food intake and fat stores before migration. To determine whether their feeding behavior is sensitive to carbohydrate and/or fatty acid utilization, white-crowned sparrows maintained on short daylength (9L15D) were injected intraperitoneally with 2-deoxy-D-glucose (2-DG) or 2,5-anhydro-D-mannitol (2,5-AM). Low doses of 2-DG (25 or 50 mg/kg) had no effect on food intake, and higher doses (100 or 300 mg/kg) significantly suppressed feeding after 1 and 2 h. No dose of 2-DG increased meal size. Similarly, low doses of 2,5-AM (25, 50, or 100 mg/kg) had no effect on food intake, and higher doses (300 and 600 mg/kg) significantly suppressed intake. These data suggest that decreased carbohydrate metabolism does not elicit feeding in this species. Importantly, these drugs, as well as insulin and glucagon, were demonstrated to increase plasma fatty acids as well as to decrease feeding. Injections of tributyrin (100, 300, 600, or 2,000 mg/kg i.p.) or glycerol (300, 450, and 600 mg/kg) also significantly suppressed 60-min and 120-min food intake dose dependently in these birds, and equimolar glucose (1,200 mg/kg) had no effect. We conclude that feeding by the white-crowned sparrow is unresponsive to manipulations of carbohydrate metabolism and is decreased after manipulations that increase plasma lipids.