Roles of Ubiquitination and Deubiquitination in Regulating Dendritic Cell Maturation and Function.
Roles of Ubiquitination and Deubiquitination in Regulating Dendritic Cell Maturation and Function.
复制标题
泛素化和去泛素化在调节树突状细胞成熟和功能中的作用。
DOI：
10.3389/fimmu.2020.586613
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发表时间：
2020
影响因子：
7.3
通讯作者：
Rui K
中科院分区：
文献类型：
--
作者：
Zhu B;Zhu L;Xia L;Xiong Y;Yin Q;Rui K
树突状细胞（Dendritic cells，DCs）是一种特异性的抗原提呈细胞，在免疫稳态和适应性免疫应答中起关键作用。DC诱导的免疫耐受或激活严格依赖于DC的不同成熟阶段和迁移能力。泛素化是一种可逆的蛋白质翻译后修饰过程，已成为调节DC成熟和功能的关键机制。最近的研究已经表明，泛素酶，包括E3泛素连接酶和去泛素酶（DUB），是DC介导的免疫功能的关键调节剂，并且用作免疫相关病症（例如，自身免疫性疾病、感染和肿瘤）。本文就泛素化在DC介导的免疫稳态和免疫应答中的分子机制及其功能的研究进展作一综述。
Dendritic cells (DCs) are specialized antigen-presenting cells that play a key role in immune homeostasis and the adaptive immune response. DC-induced immune tolerance or activation is strictly dependent on the distinct maturation stages and migration ability of DCs. Ubiquitination is a reversible protein post-translational modification process that has emerged as a crucial mechanism that regulates DC maturation and function. Recent studies have shown that ubiquitin enzymes, including E3 ubiquitin ligases and deubiquitinases (DUBs), are pivotal regulators of DC-mediated immune function and serve as potential targets for DC-based immunotherapy of immune-related disorders (e.g., autoimmune disease, infections, and tumors). In this review, we summarize the recent progress regarding the molecular mechanisms and function of ubiquitination in DC-mediated immune homeostasis and immune response.