Cerebellar-related long latency motor response in upper limb musculature by transcranial magnetic stimulation of the cerebellum
Cerebellar-related long latency motor response in upper limb musculature by transcranial magnetic stimulation of the cerebellum
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DOI：
10.1097/wnr.0b013e32836377a6
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发表时间：
2014-04-16
期刊：
影响因子：
1.7
通讯作者：
Yorifuji, Shiro
中科院分区：
文献类型：
--
作者：
Hosokawa, Sachiyo;Hirata, Masayuki;Yorifuji, Shiro
在这项研究中，我们的目的是确定出现在上肢肌肉组织的小脑相关肌电图（EMG）反应。在小脑半球上放置双锥体线圈，经颅磁刺激（TMS）平均30次，可引起双侧桡侧腕伸肌（ECR）的长潜伏期肌电反应。该EMG反应的峰值潜伏期在同侧ECR为70.7 +/- 12.7 ms，在TMS侧对侧ECR为62.9 +/- 10.2 ms。这些潜伏期比我们在枕骨大孔水平刺激锥体束的肌肉诱发电位潜伏期要长得多。通过手指目标追踪试验加载小脑半球，使同侧小脑的肌电反应更快，而对侧小脑的肌电反应更慢。此外，睡意越深，肌电图反应的峰值潜伏期就越慢。这些结果表明，该肌电电位是小脑和脑干网状结构形成的特异性反应，可能通过网状脊髓束的多突触传递从小脑结构传导到ECR肌。
In this study, we aimed to identify the cerebellum-related electromyographic (EMG) response that appeared in the upper limbs musculature. Thirty times averaged transcranial magnetic stimulation (TMS) with a double-cone coil placed over the cerebellar hemisphere elicited long latency EMG responses at the bilateral extensor carpi radialis (ECR) muscles. The peak latency of this EMG response was 70.7 +/- 12.7 ms in the ipsilateral ECR and 62.9 +/- 10.2 ms in the contralateral ECR of the TMS side. These latencies were much longer than the latency of the muscle evoked potential when we stimulated pyramidal tracts at the foramen magnum level. Cerebellar hemisphere loading by the finger target pursuit test made this EMG response faster during TMS on the ipsilateral side of the cerebellum and slower during TMS on the contralateral side of the cerebellum. Furthermore, the deeper the level of drowsiness, the slower the peak latency of this EMG response became. These results suggest that this EMG potential is a specific response of the cerebellum and brainstem reticular formation, and may be conducted from the cerebellar structure to the ECR muscle through the polysynaptic transmission of the reticulospinal tract.