Measurement of Spontaneous Oscillatory Magnetic Field of Guinea-Pig Smooth Muscle Preparation Using Pico-Tesla Resolution Amorphous Wire Magneto-Impedance Sensor
Measurement of Spontaneous Oscillatory Magnetic Field of Guinea-Pig Smooth Muscle Preparation Using Pico-Tesla Resolution Amorphous Wire Magneto-Impedance Sensor
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DOI：
10.1109/tmag.2011.2148165
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发表时间：
2011-10-01
影响因子：
2.1
通讯作者：
Nakayama, Shinsuke
中科院分区：
文献类型：
--
作者：
Uchiyama, Tsuyoshi;Mohri, Kaneo;Nakayama, Shinsuke
本文介绍了用皮特斯拉微扰传感器测量豚鼠平滑肌组织产生的自发振荡生物磁场的新结果。证实了生物磁场活动的变化与豚鼠胃肌肉细胞外电活动的变化精确同步。然而，值得注意的是，这两种活动提供了不同的生物信息。新发现的相位滞后约2秒的磁信号脉冲对细胞外的电信号脉冲。它也表明，Ca 2+通道活动的平滑肌组织（绦虫盲肠）可以使用MI传感器进行评估。电和磁活动都依赖于活组织的功能。因此，皮特斯拉MI传感器具有在广泛的生物学和医学中用于非侵入性检测的潜力，包括干细胞开发的非侵入性评估使用。
New measured results of spontaneous oscillatory bio-magnetic field generated from preparations of guinea-pig smooth muscle tissue are presented in this paper using the pico-Tesla MI sensor. It is confirmed that the changes in the bio-magnetic field activity precisely synchronized with extracellular electric activity for stomach musculature of the guinea-pig. It is, however, noteworthy that these two activities provide different biological information. A phase lag of around 2 s of the magnetic signal pulse against the extracellular electric signal pulse is newly found. It is also shown that Ca2+ channel activity of the smooth muscle tissue (taenia caeci) can be evaluated using the MI sensor. Both electric and magnetic activities depend on the functionality of the living tissues. Therefore, the pico-Tesla MI sensor has the potential for non-invasive detection use in wide range of biology and medicine, including non-invasive evaluation use of the stem cells development.