SEROREVERSION IN HUMAN IMMUNODEFICIENCY VIRUS-EXPOSED BUT UNINFECTED INFANTS
SEROREVERSION IN HUMAN IMMUNODEFICIENCY VIRUS-EXPOSED BUT UNINFECTED INFANTS
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DOI：
10.1097/00006454-199505000-00009
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发表时间：
1995-05-01
影响因子：
3.6
通讯作者：
DIAZ, C
中科院分区：
文献类型：
--
作者：
CHANTRY, CJ;COOPER, ER;DIAZ, C
这项研究的目的是描述一组暴露于人类免疫缺陷病毒但未感染的婴儿的血清逆转(SR)。对很早或很晚血清逆转的患者分组进行检查，以了解母亲或婴儿的显著临床和免疫学特征。平均时间(+/-S.D.)酶联免疫吸附试验(EL ISA)转阴时间为50.1+/-14.8周，平均11.6个月(n=84)，抗体消失时间为17.9~82.0周。免疫印迹检测血清转复的平均时间为68.3+/-12.6周，或15.8个月(n=51)，范围为44.9~94.1周。脐带血ELISA光密度(OD)测定的初始抗人类免疫缺陷病毒滴度被发现与平均血清逆转时间显著相关，而与血清逆转时间无关的因素包括胎龄、孕妇或新生儿血清免疫球蛋白浓度、孕妇CD4细胞计数、母亲饮酒、婴儿腹泻或未能茁壮成长，此处所见的血清逆转时间较长，表明1994年修订的疾病控制和预防中心对人类免疫缺陷病毒感染的定义(基于ELISA法的血清阳性和持续超过18个月的确证试验)在我们人群中是准确的。我们建议只在18个月后才使用蛋白质印迹试验作为阳性ELISA的确认。
The goal of this study was to describe sero-reversion (SR) in a cohort of human immunodeficiency virus-exposed but uninfected infants. Groups of patients who seroreverted very early or late were examined for salient clinical and immunologic characteristics of the mother or infant. The mean time (+/- s.d.) to seroreversion by enzyme-linked immunoabsorbent assay (ELISA) was 50.1 +/- 14.8 weeks, or 11.6 months (n = 84); the range of times to antibody loss by ELISA was 17.9 to 82.0 weeks. The mean time to seroreversion by Western blot was 68.3 +/- 12.6 weeks, or 15.8 months (n = 51), with a range of 44.9 to 94.1 weeks. Initial anti-human immunodeficiency virus titer as measured by cord blood ELISA optical density (OD) was found to relate significantly to mean time to seroreversion, No relationship to time to seroreversion was demonstrated for gestational age, maternal or neonatal serum immunoglobulin concentrations, maternal CD4 cell counts, maternal alcohol consumption, infantile diarrhea or failure to thrive, The lengthy time to seroreversion seen here demonstrates the 1994 revised Centers for Disease Control and Prevention definition of human immunodeficiency virus infection (based on seropositivity by both ELISA and confirmatory tests persisting beyond 18 months of age) to be accurate in our population. We recommend Western blot testing be used as confirmation for positive ELISAs only after 18 months of age.