Regio- and stereoselective ruthenium-catalyzed hydrovinylation of 1,3-dienes:: Application to the generation of a 20(S) steroidal side chain
Regio- and stereoselective ruthenium-catalyzed hydrovinylation of 1,3-dienes:: Application to the generation of a 20(S) steroidal side chain
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DOI：
10.1021/ol030031
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发表时间：
2003-05-01
期刊：
影响因子：
5.2
通讯作者：
Donaldson, WA
中科院分区：
文献类型：
--
作者：
He, ZJ;Yi, CS;Donaldson, WA
在两个钌配合物的催化下，乙烯对1,3-二烯和1-乙烯基环烯烃的加成以区域选择性的方式进行，得到3-甲基-1,4-二烯作为产物。对于甾体基1-乙烯基环烯烃，加成反应具有立体特异性，产物具有20(S)构型。
The addition of ethylene to 1,3-dienes and 1-vinylcycloalkenes, catalyzed by two ruthenium complexes, proceeds in a regioselective fashion to afford 3-methyl-1,4-dienes as products. For a steroidal-based 1-vinylcycloalkene, the addition is stereospecific, giving a product with a 20(S) configuration.