A novel tandem process leading to functionalized glutarimides
A novel tandem process leading to functionalized glutarimides
复制标题
DOI：
10.1016/j.tetlet.2005.02.087
复制
发表时间：
2005-04-11
影响因子：
1.8
通讯作者：
Kiricojevic, VD
中科院分区：
文献类型：
--
作者：
Popovic-Dordevic, JB;Ivanovic, MD;Kiricojevic, VD
公开了通过新的串联方法合成各种官能化或螺双环戊二酰亚胺。该反应包括活性亚甲基化合物与二级共轭酰胺的碱催化迈克尔加成，然后是羧酰胺基的分子内N-酰化。它提供了一个相对普遍和简单的访问有用的合成中间体和潜在的活性药理化合物。此外，还合成了一组新的螺双环体系。(c)2005爱思唯尔有限公司保留所有权利。
The synthesis of various functionalized or spirobicyclic glutarimides by a novel tandem process has been disclosed. The reaction involves a base-catalyzed Michael addition of active methylene compounds to secondary conjugated amides, followed by intramolecular N-acylation of the carboxamido group. It provides a relatively general and simple access to useful synthetic intermediaries and potentially active pharmacological compounds. In addition, a novel group of spirobicyclic systems has been synthesized. (c) 2005 Elsevier Ltd. All rights reserved.