Follow-up of Children Born after ART
Follow-up of Children Born after ART
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DOI：
10.1016/j.placenta.2008.08.013
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发表时间：
2008-10-01
期刊：
影响因子：
3.8
通讯作者：
Sutcliffe, A.
中科院分区：
文献类型：
--
作者：
Basatemur, E.;Sutcliffe, A.
辅助生殖治疗(ART)，即体外受精(IVF)和卵胞浆内单精子注射(ICSI)，已广泛应用于人类不孕症的治疗。使用ART技术受孕的儿童占人口的相当大比例。有必要对这些儿童进行随访，以评估随后受孕的后代接受不孕治疗的风险。近年来，在这一领域开展了大量的工作。这篇综述总结了目前关于抗逆转录病毒治疗后怀孕的儿童健康的证据，包括新生儿结局、先天性畸形的风险、神经发育结局、身体健康、心理社会健康和癌症风险。对ART儿童未来福祉的主要风险仍然是多胎妊娠和低出生体重。关于按ART技术足月出生的独生子女结局的证据通常是令人放心的。在艺术儿童从青春期到成年期的过程中，继续对他们进行跟踪是至关重要的。(C)2008爱思唯尔有限公司。保留所有权利
Assisted reproductive therapies (ART), namely in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI), have become widely used in the treatment of human infertility. Children conceived using ART represent a substantial proportion of the population. Follow-up of these children is necessary in order to evaluate the risks of infertility treatment upon subsequently conceived offspring. In recent years there has been considerable work in this field. This review summarises current evidence regarding the health of children conceived following ART, encompassing neonatal outcomes, the risk of congenital malformations, neurodevelopmental outcome, physical health, psychosocial well being, and the risk of cancer. The main risks for the future well being of ART children remain multiple pregnancies and low birth weight. Evidence regarding the outcome of singletons born at term following ART is generally reassuring. It is essential that follow-up of ART children continues as they progress through adolescence into adulthood. (C) 2008 Elsevier Ltd. All rights reserved