Diagnostic Problems in Cerebrospinal Fluid of Children with Lymphoid Malignancies
Diagnostic Problems in Cerebrospinal Fluid of Children with Lymphoid Malignancies
复制标题
儿童淋巴恶性肿瘤脑脊液的诊断问题
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
A. Ritchey
中科院分区：
文献类型：
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作者：
S. Mcintosh;A. Ritchey
对患有淋巴恶性肿瘤的儿童的脑脊液（CSF）中少量淋巴母细胞或非特异性细胞增多症的解释是困难的。在这项204例患者的前瞻性研究中。15例患者的白色细胞室计数>M10个细胞/μl，细胞离心涂片上有一个或多个原始细胞。只有3/15随后发展成脑膜白血病，4/15保持持续完全缓解。在53例白细胞计数>10 WBC/μl且无原始细胞的患者中，半数患者的白细胞增多与中枢神经系统（CNS）预防相关。不太常见的是病毒综合征、免疫恢复、随后的脑膜白血病、活动性血液白血病、嗜睡综合征、白质脑病或对既往创伤性腰椎穿刺的反应。
The interpretation of small numbers of lymphoblasts or of nonspecific pleocytosis in the cerebrospinal fluid (CSF) of children with lymphoid malignancies is difficult. In this prospective study of 204 patients. 15 had white cell chamber counts of >M10 cells/μl, with one or more blasts on a cytocentrifuged smear. Only 3/15 subsequently developed meningeal leukemia, and 4/15 remain in continuous complete remission. Among 53 patients with a chamber count >10 WBC/μl and no blasts, pleocytosis was associated with central nervous system (CNS) prophylaxis in half. Less common were viral syndromes, immune recovery, subsequent meningeal leukemia, active hematologic leukemia, the somnolence syndrome, leukoencephalopathy, or reaction to a previous traumatic lumbar puncture.