Global geographical overlap of aflatoxin and hepatitis C: controlling risk factors for liver cancer worldwide
Global geographical overlap of aflatoxin and hepatitis C: controlling risk factors for liver cancer worldwide
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DOI：
10.1080/19440049.2012.751630
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发表时间：
2013-03-01
影响因子：
2.9
通讯作者：
Wu, F.
中科院分区：
文献类型：
--
作者：
Palliyaguru, D. L.;Wu, F.
大约85%的肝细胞癌（HCC，肝癌）病例发生在低收入国家，在这些国家，饮食黄曲霉毒素暴露和慢性B肝炎和丙型肝炎（HBV和HCV）病毒感染的风险因素很常见。虽然研究表明黄曲霉毒素和HBV在引起HCC方面具有协同作用，但关于黄曲霉毒素和HCV是否具有类似的协同作用却知之甚少。从暴露的角度来看，研究了全球暴露于高饮食黄曲霉毒素水平和高HCV流行率的人群是否存在地理重叠。虽然HCV是高收入国家（黄曲霉毒素暴露低）HCC最重要的风险因素之一，但发现HCV在非洲和亚洲的患病率要高得多，黄曲霉毒素暴露也很高。然而，在特定的世界区域内，在接触和癌症风险方面存在一些不一致。因此，有必要以具有成本效益的方式控制黄曲霉毒素和肝炎病毒等风险因素，以预防全球HCC，同时继续评估这些风险因素相互作用增加HCC风险的生物学机制。
About 85% of hepatocellular carcinoma (HCC, liver cancer) cases occur in low-income countries, where the risk factors of dietary aflatoxin exposure and chronic hepatitis B and C (HBV and HCV) viral infection are common. While studies have shown synergism between aflatoxin and HBV in causing HCC, much less is known about whether aflatoxin and HCV synergise similarly. From an exposure perspective, it was examined whether there is a geographical overlap in populations worldwide exposed to high dietary aflatoxin levels and with high HCV prevalence. While HCV is one of the most important risk factors for HCC in high-income nations (where aflatoxin exposure is low), it is found that HCV prevalence is much higher in Africa and Asia, where aflatoxin exposure is also high. However, within a given world region, there are some inconsistencies regarding exposure and cancer risk. Therefore, there is a need to control risk factors such as aflatoxin and hepatitis viruses in a cost-effective manner to prevent global HCC, while continuing to evaluate biological mechanisms by which these risk factors interact to increase HCC risk.