Additive batch electrospinning patterning of tethered gelatin hydrogel fibres with swelling-induced fibre curling
Additive batch electrospinning patterning of tethered gelatin hydrogel fibres with swelling-induced fibre curling
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DOI：
10.1016/j.addma.2020.101456
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发表时间：
2020-12-01
影响因子：
11
通讯作者：
Huang, Yan Yan Shery
中科院分区：
文献类型：
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作者：
Gill, Elisabeth L.;Wang, Wenyu;Huang, Yan Yan Shery
有限的方法存在集成自由跨越水凝胶微纤维的图案作为增材制造战略的一部分。我们演示了3D添加剂批量静电纺丝（3D- abes）工作流程，以有效地生产层状水凝胶明胶微纤维，连接到各种形状的3D打印热塑性结构。通过数字设计方法，多个3D打印纤维设备可以高效地批量制造，样品间方差最小。定制的纤维模式和器件几何形状可以快速改变，以适应6至24孔板格式的潜在应用。生产的干纤维的直径在2 - 4 μ m的范围内。随着该设备在水环境中的应用，我们研究了加工参数组合对明胶纤维完整性的影响，以及它在浸入水中时的膨胀行为。在参数化研究的帮助下，膨胀引起的纤维卷曲的模式，从直线到波浪，可以调整。我们的研究结果可以作为优化由交联亲水性聚合物和低聚物制成的电纺水凝胶样纤维的3D制造和图案的指南，用于细胞培养或生物传感应用。
Limited methods exist to integrate patterning of free-spanning hydrogel microfibres as part of an additive manufacturing strategy. We demonstrate 3D additive batch electrospinning (3D-abES) workflow to efficiently produce layered hydrogel gelatin microfibres, tethered to 3D printed thermoplastic structures of various shapes. Enabled by the digital-design approach, multiple 3D printed fibre devices can be fabricated in a batch efficiently with minimised sample-to-sample variance. Customised fibre patterns and device geometries can be rapidly altered to fit with potential applications in 6- to 24- well plate formats. The diameter of as-produced dry fibres is in a range of similar to 2 - 4 mu m. With the intended device applications in aqueous environments, we investigate the effect of combinations of processing parameters on the gelatin fibre integrity, and its swelling behaviour when immersed in water. Aided by the parametric study, patterns of swelling-induced fibre curling, from straight to wavy, can be tuned. Our findings could serve as a guide to optimise the 3D fabrication and patterning of electrospun hydrogel-like fibres made of crosslinked hydrophilic polymers and oligomers, for cell culture or biosensing applications.