Qualitative and quantitative ultrashort echo time (UTE) imaging of cortical bone
Qualitative and quantitative ultrashort echo time (UTE) imaging of cortical bone
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DOI：
10.1016/j.jmr.2010.09.013
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发表时间：
2010-12-01
影响因子：
2.2
通讯作者：
Bydder, Graeme M.
中科院分区：
文献类型：
--
作者：
Du, Jiang;Carl, Michael;Bydder, Graeme M.
我们描述了使用二维超短回波时间（2D UTE）序列，最小TE为8 μ s，在临床3 T扫描仪上对皮质骨进行成像和量化。绝热反转脉冲用于长T（2）水和脂肪信号抑制。绝热反转制备的具有不同TE的UTE采集用于T（2）测量。饱和恢复UTE采集用于T（1）测量。借助外部参考体模测量骨水浓度。在尸体标本和健康志愿者上评价了UTE技术。信噪比约为30，在体内胫骨中，骨和肌肉/脂肪之间的对比度噪声比约为27/20，标称体素尺寸为0.23 x 0.23 x 6.0 mm（3），扫描时间为5 min。平均T1为223 +/- 11 ms，平均T（2）为390 +/-在5名正常志愿者的胫骨中，发现平均骨水浓度为23.3 +/- 1.6%（采用UTE）和21.7 +/- 1.3%（采用绝热反转制备的UTE序列）。结果表明，2D UTE序列对皮质骨进行活体定性和定量评价是可行的。(C)2010年爱思唯尔公司All rights reserved.
We describe the use of two-dimensional ultrashort echo time (2D UTE) sequences with minimum TEs of 8 mu s to image and quantify cortical bone on a clinical 3T scanner. An adiabatic inversion pulse was used for long T(2) water and fat signal suppression. Adiabatic inversion prepared UTE acquisitions with varying TEs were used for T(2) measurement. Saturation recovery UTE acquisitions were used for T(1) measurement. Bone water concentration was measured with the aid of an external reference phantom. UTE techniques were evaluated on cadaveric specimens and healthy volunteers. A signal-to-noise ratio of around 30, contrast-to-noise ratio of around 27/20 between bone and muscle/fat were achieved in tibia in vivo with a nominal voxel size of 0.23 x 0.23 x 6.0 mm(3) in a scan time of 5 min. A mean T1 of 223 +/- 11 ms and mean T(2) of 390 +/- 19 mu s were found. Mean bone water concentrations of 23.3 +/- 1.6% with UTE and 21.7 +/- 1.3% with adiabatic inversion prepared UTE sequences were found in tibia in five normal volunteers. The results show that in vivo qualitative and quantitative evaluation of cortical bone is feasible with 2D UTE sequences. (C) 2010 Elsevier Inc. All rights reserved.