Synthesis of anthraquinone oligonucleotides for triplex stabilization.
Synthesis of anthraquinone oligonucleotides for triplex stabilization.
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用于三链体稳定的蒽醌寡核苷酸的合成。
DOI：
10.1080/15257770701506491
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Zhao Z
中科院分区：
文献类型：
--
作者：
Zhao Z
介绍了两种蒽醌亚磷酰胺的合成方法。在这两种情况下，蒽醌部分通过接头连接到尿嘧啶碱基的5位，允许在寡核苷酸序列中的任何胸苷位置掺入。蒽醌修饰的寡核苷酸作为三链体稳定剂和荧光猝灭剂具有潜在的应用前景。
The synthesis of two anthraquinone phosphoramidites is described. In both cases the anthraquinone moiety is attached via a linker to the 5-position of a uracil base, allowing incorporation at any thymidine position in an oligonucleotide sequence. Anthraquinone-modified oligonucleotides have potential applications as triplex stabilizers and fluorescence quenchers.