Elevated monocyte chemoattractant protein-1 serum levels in patients at risk for coronary artery disease
Elevated monocyte chemoattractant protein-1 serum levels in patients at risk for coronary artery disease
复制标题
DOI：
10.1253/circj.69.1484
复制
发表时间：
2005-12-01
影响因子：
3.3
通讯作者：
Lindemann, S
中科院分区：
文献类型：
--
作者：
Martinovic, I;Abegunewardene, N;Lindemann, S
背景单核细胞趋化蛋白-1(MCP-1)参与了单核细胞向动脉壁的募集，是导致动脉粥样硬化性血管疾病(如冠心病)的主要事件之一。采用双抗体夹心酶联免疫吸附试验测定血清MCP-1水平。在每个患者中，评估冠状动脉危险因素(CRF)，如高血压、高胆固醇、糖尿病、肥胖、阳性家族史和吸烟。测定低密度脂蛋白胆固醇、脂蛋白(A)和血红蛋白A(1C)水平。经血管造影证实的冠心病患者MCP-1水平显著升高。在非冠心病患者中，MCP-1的升高依赖于CRF的数量。作为血管内皮细胞活化的标志物，检测了冠心病和多发性CRF患者血清中可溶性黏附分子、可溶性细胞间黏附分子和可溶性E-选择素的水平，并与非CRF组比较均有显著差异。虽然这不是直接证据，但内皮激活可能导致动脉粥样硬化患者MCP-1水平升高。结论MCP-1血清水平升高可作为冠状动脉和其他动脉粥样硬化性血管疾病高危患者炎症活动的直接标志。
Background Monocyte chemoattractant protein-1 (MCP-1) is involved in the recruitment of monocytes into the arterial vessel wall as one of the major events leading to atherosclerotic vascular diseases, such as coronary artery disease (CAD).Methods and Results The study group comprised 263 volunteers aged between 18 and 85 years who were admitted to hospital or clinic for scheduled invasive and non-invasive diagnostic procedures. MCP-1 serum levels were determined using a sandwich-enzyme-linked immunosorbent assay. In each patient, the coronary risk factors (CRF), such as hypertension, high cholesterol, diabetes mellitus, obesity, positive family history, and smoking were evaluated. Low-density lipoprotein-cholesterol, lipoprotein(a), and hemoglobinA(1C) levels were determined. Patients with CAD proven by angiography had significantly increased MCP-1 levels. In patients without CAD, the increase in MCP-1 depended on the number of CRF. As a marker for endothelial activation the soluble adhesion molecules, soluble intercellular adhesion molecule and soluble E-selectin were measured and both markers were significantly elevated in patients with CAD or multiple CRF when compared with patients without CRF. Although this is not a direct proof, endothelial activation could contribute to elevated MCP-1 levels in atherosclerosis.Conclusion Elevated MCP-1 serum levels could serve as a direct marker of the inflammatory activity in patients at risk for coronary artery and other atherosclerotic vascular diseases.