Condensation of actin filaments pushing against a barrier
Condensation of actin filaments pushing against a barrier
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肌动蛋白丝的凝结推动屏障
DOI：
10.1088/1367-2630/13/10/103032
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发表时间：
2011
影响因子：
3.3
通讯作者：
J. Joanny
中科院分区：
文献类型：
--
作者：
K. Tsekouras;D. Lacoste;K. Mallick;J. Joanny
我们开发了一个模型来描述由一系列平行生物细丝聚合产生的力。假设细丝仅通过与可移动屏障的机械接触来耦合。我们用平均场方法结合模拟计算了细丝密度分布和力-速度关系。我们确定了两个区域：在低力下的非凝聚区域，其中细丝在空间上展开；以及在高力下，细丝在势垒附近聚集。我们证实了以前从其他相关研究中已知的一个结果，即失速力等于单根灯丝失速力的N倍。在本文研究的模型中，接近失速的速度非常慢，在显著低于失速力的力的情况下，速度几乎为零。
We develop a model to describe the force generated by the polymerization of an array of parallel biofilaments. The filaments are assumed to be coupled only through mechanical contact with a movable barrier. We calculate the filament density distribution and the force–velocity relation with a mean-field approach combined with simulations. We identify two regimes: a non-condensed regime at low force in which filaments are spread out spatially and a condensed regime at high force in which filaments accumulate near the barrier. We confirm a result previously known from other related studies, namely that the stall force is equal to N times the stall force of a single filament. In the model studied here, the approach to stalling is very slow, and the velocity is practically zero at forces significantly lower than the stall force.
影响因子：
3.4
作者：
Atilgan, E;Wirtz, D;Sun, SX
通讯作者：
Sun, SX
影响因子：
3.4
作者：
Carlsson, AE
通讯作者：
Carlsson, AE
DOI：
10.1073/pnas.0405902101
发表时间：
2004-10-12
影响因子：
11.1
作者：
Kovar, DR;Pollard, TD
通讯作者：
Pollard, TD