Glutamate imaging (GluCEST) lateralizes epileptic foci in nonlesional temporal lobe epilepsy.
Glutamate imaging (GluCEST) lateralizes epileptic foci in nonlesional temporal lobe epilepsy.
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DOI：
10.1126/scitranslmed.aaa7095
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发表时间：
2015-10-14
影响因子：
17.1
通讯作者：
Reddy R
中科院分区：
文献类型：
--
作者：
Davis KA;Nanga RP;Das S;Chen SH;Hadar PN;Pollard JR;Lucas TH;Shinohara RT;Litt B;Hariharan H;Elliott MA;Detre JA;Reddy R
When neuroimaging reveals a brain lesion, drug-resistant epilepsy patients show better outcomes after resective surgery than do the one-third of drug resistant epilepsy patients who have normal brain MRIs. We applied a glutamate imaging method, GluCEST (Glutamate Chemical Exchange Saturation Transfer), to patients with non-lesional temporal lobe epilepsy (TLE) based on conventional MRI. GluCEST correctly lateralized the temporal lobe seizure focus on visual and quantitative analysis in all patients. MR spectra, available in a subset of patients and controls, corroborated the GluCEST findings. Hippocampal volumes were not significantly different between hemispheres. GluCEST allowed for high-resolution functional imaging of brain glutamate and has potential to identify the epileptic focus in patients previously deemed non-lesional. This method may lead to improved clinical outcomes for temporal lobe epilepsy as well as other localization-related epilepsies.
