Cardiovascular disease and risk factors among psoriasis patients in two US Healthcare databases, 2001-2002
Cardiovascular disease and risk factors among psoriasis patients in two US Healthcare databases, 2001-2002
复制标题
DOI：
10.1159/000121333
复制
发表时间：
2008-01-01
期刊：
影响因子：
3.4
通讯作者：
Bala, M.
中科院分区：
文献类型：
--
作者：
Kimball, A. B.;Robinson, D., Jr.;Bala, M.
背景：心血管疾病或危险因素 (CVDR) 在银屑病患者中似乎比一般人群更常见。目的：我们使用横断面、基于患病率的研究设计，通过分析医疗保健索赔数据，评估了银屑病与 CVDR 的关系。患者和方法：IMS Health 和 MarketScan (R) 索赔数据库用于识别具有银屑病诊断代码的成年人。根据年龄、性别、人口普查地区和既往医疗保险覆盖范围，将非银屑病对照进行 3:1 匹配。比值比评估了 CVDR 的相对患病率，并估计了 Mantel-Haenszel 置信区间。结果：在两个数据集中，银屑病患者的 CVDR 患病率普遍高于对照组。银屑病患者发生动脉粥样硬化、充血性心力衰竭、2 型糖尿病和周围血管疾病的比值比 >= 1.20。疾病严重程度升高与 CVDR 发生率升高相关，但因数据集和病情的不同而有所不同。结论：与对照组相比，银屑病患者的 CVDR 率升高。这种模式值得进一步检验。版权所有 (C) 2008 S. Karger AG，巴塞尔。
Background: Cardiovascular diseases or risk factors ( CVDR) seem to be more common in psoriasis patients than in the general population. Objective: We assessed the relationship of psoriasis with CVDR by analysis of healthcare claims data using a cross-sectional, prevalence-based study design. Patients and Methods: The IMS Health and MarketScan (R) claims databases were used to identify adults with psoriasis diagnostic codes. Non-psoriasis controls were matched 3: 1 based on age, gender, census region and previous medical insurance coverage. Odds ratios evaluated the relative prevalence of CVDR, and Mantel-Haenszel confidence intervals were estimated. Results: CVDR prevalence was generally higher in psoriasis patients than controls in both datasets. Odds ratios for atherosclerosis, congestive heart failure, type 2 diabetes, and peripheral vascular disease were >= 1.20 for psoriasis patients. Elevated disease severity was associated with a higher rate of CVDR, but varied somewhat by dataset and condition. Conclusions: Elevated CVDR rates were found in psoriasis patients compared with controls. This pattern merits further examination. Copyright (C) 2008 S. Karger AG, Basel.