Installing Logic Gates to Multiresponsive Supramolecular Hydrogel Co-assembled from Phenylalanine Amphiphile and Bis(pyridinyl) Derivative
Installing Logic Gates to Multiresponsive Supramolecular Hydrogel Co-assembled from Phenylalanine Amphiphile and Bis(pyridinyl) Derivative
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将逻辑门安装到由苯丙氨酸两亲物和双（吡啶基）衍生物共同组装的多响应超分子水凝胶中
DOI：
10.1021/acs.langmuir.5b01585
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发表时间：
2015-06-30
期刊：
影响因子：
3.9
通讯作者：
Feng, Chuan-Liang
中科院分区：
文献类型：
--
作者：
Liu, Guo-Feng;Ji, Wei;Feng, Chuan-Liang
近年来，基于多响应水凝胶系统的逻辑门因其潜在的生物学应用而备受关注。由苯丙氨酸基两亲物（LPP 2）和双（吡啶基）衍生物（AP）共组装而成的一种非常简单的超分子水凝胶。共组装的水凝胶响应于四种不同的输入刺激（温度、酸、碱和光）表现出宏观凝胶-溶胶转变。一组技术，包括显微镜，光谱和流变学测量证明了这种性能，并确认水凝胶是通过酰胺/吡啶部分和羰基之间的分子间氢键形成。基于凝胶超分子的多刺激响应性，实现了凝胶超分子逻辑门（或门和异门）的安装。它可以促进开发智能软材料的可能性，例如凝胶，其可以用作通过合理设计和精细控制外部刺激来定量释放药物的工具。
Recently, logic gates based on multiresponsive hydrogel Systems are attractive because of their potential biological applications.,A quite simple supramolecular hydrogel co-assembled from phenylalanine-based amphiphile (LPP2) and bis(pyridinyl) derivative (AP) is constructed. The co-assembled hydrogel exhibited a macroscopic gel-sol transition in response to four distinct input Stimuli: temperature, acid, base, and light. A set of techniques including microscopic, spectroscopic, and theological measurements demonstrate this performance and confirm that the hydrogel is formed through intermolecular hydrogen bonds between amide/pyridine moieties and carbonyl groups. On the basis Of its mutiple-stimulus responsiveness, installing gel-based supramolecular logic gates (OR and XOR) is achieved. It may promote the possibility to develop smart soft materials, such as gels, that can be used as tools releasing a drug quantitatively by rational design and fine control of the external stimuli.