Population-Specific Susceptibility to Crohn's Disease and Ulcerative Colitis; Dominant and Recessive Relative Risks in the Japanese Population
Population-Specific Susceptibility to Crohn's Disease and Ulcerative Colitis; Dominant and Recessive Relative Risks in the Japanese Population
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DOI：
10.1111/j.1469-1809.2010.00567.x
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发表时间：
2010-03-01
影响因子：
1.9
通讯作者：
Oota, Hiroki
中科院分区：
文献类型：
--
作者：
Nakagome, Shigeki;Takeyama, Yasuaki;Oota, Hiroki
P>；Crohn病(CD)是一种慢性炎症性肠病(IBD)，常见于欧洲和东亚国家。CD的计算遗传率似乎高于IBD的另一种类型溃疡性结肠炎(UC)。最近的全基因组关联研究已经在欧洲人群中确定了30多个与CD相关的基因/区域。然而，在东亚人群中，只有在TNFSF15中才能检测到CD和相关基因之间的明显关联。为了确定Cd的易感性是否在地理上不同，我们选择了来自7个欧洲Cd相关基因组区域的9个SNPs进行分析。比较了收集的380份日本样本中这些SNPs的基因频率，其中包括212例IBD患者和168名对照。我们检测到CD和UC仅与TNFSF15基因显著相关。改良的基因型相对风险检验(MGRR)分析表明，TNFSF15对CD为显性易感基因，对UC为隐性易感等位基因。这些结果表明日本人和欧洲人对CD和UC的易感性不同。此外，CD和UC也可能具有共同的致病因素，在日本人群中表现出不同的显性/隐性相对风险。
P>Crohn's disease (CD), a type of chronic inflammatory bowel disease (IBD), is commonly found in European and East Asian countries. The calculated heritability of CD appears to be higher than that of ulcerative colitis (UC), another type of IBD. Recent genome-wide association studies (GWAS) have identified more than thirty CD-associated genes/regions in the European population. In the East Asian population, however, a clear association between CD and an associated gene has only been detected with TNFSF15. In order to determine if CD susceptibility differs geographically, nine SNPs from seven of the European CD-associated genomic regions were selected for analysis. The genotype frequencies for these SNPs were compared among the 380 collected Japanese samples, which consisted of 212 IBD cases and 168 controls. We detected a significant association of both CD and UC with only the TNFSF15 gene. Analysis by the modified genotype relative risk test (mGRR) indicated that the risk allele of TNFSF15 is dominant for CD, but is recessive for UC. These results suggest that CD and UC susceptibility differs between the Japanese and European populations. Furthermore, it is also likely that CD and UC share a causative factor which exhibits a different dominant/recessive relative risk in the Japanese population.